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Assignment:
Scenario: A longitudinal study aims to investigate the relationship between a high-fat diet and the development of cardiovascular disease (CVD). The study population consists of middle-aged adults living in an urban area. Preliminary results suggest a strong association between a high-fat diet and increased risk of CVD. However, the researchers are concerned about potential confounding factors and various forms of bias that may affect the study's outcomes.
Question: Based on this scenario, please help me to perform a detailed analysis of potential sources of confounding and bias. Address the following points:
1. Identification of confounders: Identify at least three potential confounding variables that could influence the relationship between a high-fat diet and CVD. Explain how each confounder could affect the observed association.
2. Strategies to control confounding: For each identified confounder, propose a method to control its impact on the study. Discuss the effectiveness and limitations of these methods.
3. Types of bias: Identify and describe the sources of selection bias and information bias that could be present in this study.
4. External validity: Discuss how the setting of the study might influence the study's external validity.
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