Receiving investigational antibiotic

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Question

CM is a 50-year-old man receiving an investigational antibiotic. Based on phase 1 studies, the half-life in healthy subjects is constant at 8 hours. The average V in the volunteers was 0.5 L/kg based on total body weight. The drug is hepatically metabolized. CM weighs 80 kg. The desired peak is 28 mcg/mL (25-30 acceptable), and the trough must be under 5 mcg/mL to avoid toxicity, but should be above 3. It is always infused over 1h. Assume 1-compartment kinetics.

Based on population kinetics, which of the following is the most appropriate dosing regimen?

A) 3600 mg q24h

B) 1.8 mg q12h

C) 2.6 mg q24h

D) 1800 mg q12h

Reference no: EM133957045

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