Randomized trials on effect of combined cognitive therapy

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A group of EBP nurses is looking at study results from 8 randomized trials on the effect of combined cognitive therapy and pharmacological treatment on positive and negative symptoms in patients with schizophrenia. They wonder when to rate down the quality of evidence due to inconsistent findings. Which of the following scenarios indicate the need to downgrade the quality of evidence?: The tests of heterogeneity results was p = 0.001 but the variations in study results are due to differences in treatment adherence across studies, The tests of heterogeneity results was p = 0.23 and the variations in treatment adherence were similar between intervention and control groups, The Confidence Intervals for the effect size among the 8 studies had little overlap and the variations cannot be explained by the duration of follow-up, The Confidence Intervals for the effect size among the 8 studies had little overlap but the variations can be explained by the duration of follow-up/

Reference no: EM133848586

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