Primary mechanism responsible for termination

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Questions

1. Explain the primary mechanism responsible for termination or breakdown of serotonergic transmission meaning what deactivates serotonin. Name an important class of drugs that acts on that mechanism and make sure you list at least one drug in this category.

2. Although memantine and ketamine are thought to bind in a very similar location within the NMDA receptor channel, they have major differences and are used for different purposes. Describe the effects of these drugs in detail and the ways they differ in terms of mode of action.

3. Describe how storage and release of acetylcholine is affected by the following: vesamicol, black widow spider venom, and botulinum toxin. How is botulinum toxin being used in therapeutic and cosmetic settings today?

4. Describe in detail some of the risk factors for developing drug addiction and some of the protective factors that may reduce risk.

5. Compare and contrast the sympathetic and parasympathetic divisions of the autonomic nervous system in detail. Also explain how drugs can mimic sympathetic and parasympathetic nervous systems and give examples of each.

6. Identify the major pieces of federal drug legislation and the purpose of each. What effect did these laws have on drug use in the United States?

Reference no: EM133990767

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