Pharmacokinetics between sodium valproate and valproic acid

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Reference no: EM133870773

Before we get too far into hyperlipidemia-high cholesterol in the blood-we should have a grounding in what cholesterol is and what it does. Cholesterol is a fat-like substance (often, it's referred to as "waxy") that's used by your body to make vitamin D, hormones, and substances that aid in digestion. It is necessary for your body to function properly.

1. I'd like to know the possibility of giving these drugs in epileptics: vincamine (Oxicebral), cinnarizine, piribedil (Trivastal) and pentoxyphylline (Trental). I'd like to know if they are contraindicated.

2. If an epileptic patient, treated with oxcarbazepine, develops a rash, should this drug be withdrawn or the dosage decreased and then increased gradually again?

3. Does a patient with refractory epilepsy benefit from acetazolamide?

4. What anti-epileptic drug is recommended for a child with epilepsy and co-morbid attention deficit hyperactivity disorder (ADHD)? Can Ritalin safely be used for treatment?

5. What is the difference in efficacy and pharmacokinetics between sodium valproate and valproic acid?

6. Is it safe to give valproic acid to infants below 12 months of age?

7. How many times must the liver transaminases (SGOT and SGPT) rise to justify a discontinuation of valproic acid therapy in children? Which of these enzymes is more sensitive and reliable in this situation?

8. 1. Does valproic acid block the photosensitivity phenomenon in reflex epilepsy?

2. Can a patient with this photosensitivity be safely exposed to computer games or other photic stimuli when receiving valproic acid treatment?

3. Does the photosensitivity phenomenon occur in partial seizures?

9. 1. Can an epileptic fit be induced in idiopathic and symptomatic focal epilepsy syndromes by flickering lights?

2. Is valproate effective against the photosensitive phenomenon (seizure induction by flickering light)?

10. How much time should one give before a loading dose of phenytoin is judged to be ineffective in controlling seizures and an alternative should be instituted?

Reference no: EM133870773

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