Opioid-induced constipation

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Reference no: EM133789521

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Opioid-induced constipation can be managed with a combination of pharmacologic and nonpharmacologic measures. The goal is to produce a soft, formed stool every 1 to 2 days. Principal nondrug measures are physical activity and increased intake of fiber and fluids (for prevention) and enemas (for treatment). Most patients also require prophylactic drugs: a stimulant laxative, such as senna, is given to counteract reduced bowel motility, plus polyethylene glycol (an osmotic laxative) can provide additional benefit. If these prophylactic drugs prove inadequate, the patient may need rescue therapy with a strong osmotic laxative, such as lactulose or sodium phosphate. As a last resort, patients may be given methylnaltrexone (Relistor), an oral drug that blocks µ receptors in the intestine.

Reference no: EM133789521

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