Metastatic castration-resistant prostate cancer

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Reference no: EM133866955

Question

A 58-year-old man with metastatic castration-resistant prostate cancer (mCRPC) is started on abiraterone (CYP17 inhibitor in prostate cancer lecture) with prednisone. Genetic testing reveals he is a CYP3A4 ultra-rapid metaboliser. Which side effect should the nurse prioritise monitoring for, based on the drug's mechanism and the patient's pharmacogenetics?

Hypokalemia due to abiraterone-induced hyperaldosteronism Hepatotoxicity from reactive metabolite buildup in CYP3A4 ultra-rapid metabolisers Adrenal insufficiency from excessive cortisol suppression Hypercalcemia due to osteoblastic flare from rapid androgen deprivation.

Reference no: EM133866955

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