Metabolic processes-methylation and glucuronidation

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Question

1. Explain the types of Phase II metabolic processes- methylation, glucuronidation, acetylation, sulfation, and conjugation.

2. Explain, in detail, how the Ames test works and why it is an important biomarker tool (include S9 activation in answer).

3. Explain how CYP450 system detoxifies xenobiotics and how in a world full of xenobiotics, does this system also cause physiologic harm?

4. Explain the lethal toxicological/physiological effect(s) of neonicotinoids on insects and then explain sublethal effects.

5. Explain why it is so difficult to predict the outcome(s) for agonists of aryl hydrocarbon receptors.

Reference no: EM133436450

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