Mechanism of action of first-generation antihistamines

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What statement best describes the mechanism of action of first-generation antihistamines? First generation antihistamines nonselectively stimulate central and peripheral histamine H1 receptors, thereby producing a sedating effect. First generation antihistamines selectively antagonize central histamine H1 receptors, thereby producing a sedating effect. First generation antihistamines nonselectively antagonize central and peripheral histamine H1 receptors, thereby producing a sedating effect. First generation antihistamines selectively antagonize peripheral histamine H1 receptors, thereby producing a sedating effect.

Reference no: EM133875248

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