History of chronic cough and sputum production

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An older adult patient presents with a 10-year history of chronic cough and sputum production, particularly in the mornings. She has smoked 1 pack of cigarettes daily for 45 years but quit last year. Post bronchodilator FEV1/FVC ratio of 0.65. Which of the following pathophysiological processes is most directly responsible for the excessive mucus production observed in this condition.

Reference no: EM133633390

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