Explain why acyl-glucuronides are thought to be toxic

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Assignment:

It has been suggested that glucuronides of drugs that contain carboxylic acid functional groups (acyl-glucuronides or ester glucuronides) may be responsible for some of the toxicity associated with long-term use of such drugs. Explain why acyl-glucuronides are thought to be toxic. Give an example of a drug for which this mechanism has been suggested, including a literature reference.

Reference no: EM134041690

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