Explain the pharmacodynamics and toxicokinetic

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Assignment:

Explain in detail the pharmacodynamics and toxicokinetic (absorption, distribution, Metabolism, and elimination) of kratom. (Includes the window of detection based on route of exposure, how kratom is absorbed orally as capsule or tea, snorting/nasal insufflation, intravenously, bioavailability of the drug regarding the route of exposure, how kratom is metabolized into its metabolites (active and inactive), how is kratom or its metabolites distributed in the brain in regards to synaptic cleft, neurotransmitters and receptors involves in the kratom's distribution, how it is eliminated through the kidney from the moment kratom or it metabolites enter the Bowman's Capsule through to the descending and ascending loop of Henle, distal convoluted tubule and so on).

Reference no: EM133383498

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