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A 46 yo woman with ulcerative colitis has been treated for 12 months with prednisone. She is in remission and has recently been treated for a broken ankle after a minor fall.
1. Explain the mechanism of action for prednisone and why it is useful for the treatment of this patient. Include in your discussion the mode of administration, the binding to receptors, receptor action, and drug metabolism
2. Based on the potencies of glucocorticoids, draw a relative EC50 curve for prednisone and compare the curve to dexamethasone and hydrocortisone
3. What concerns do you have for this patient with respect to her broken ankle?
4. If the decision is made to stop the prednisone, what procedure should be followed and why?
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