Excessive mechanical stress triggers inflammation

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Reference no: EM133879454

DISCUSSION

In osteoarthritis, excessive mechanical stress triggers inflammation, leading to cartilage degradation through the release of enzymes and inflammatory mediators (NOS, IL-6, and IL-8) (He et al., 2020; Yunus et al., 2020). Repetitive movement or overuse disrupts the balance of the joint, leading to cartilage breakdown and the progression of OA. Mechanical stress leads to microtrauma in the cartilage, triggering the release of inflammatory mediators that further degrade the extracellular matrix (ECM), creating a cycle of damage and inflammation (He et al., 2020). While mechanical stress is a primary driver, inflammation plays a significant role in OA, contributing to pain, cartilage degradation, and joint damage. Inflammatory mediators like cytokines directly damage cartilage and stimulate the release of enzymes called matrix metalloproteinases (MMPs) that break down cartilage (Rogers, 2023; Yunus et al., 2020)

Reference no: EM133879454

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