Diabetes prevention program

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Reference no: EM133868818

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A landmark study was published in 2002 on lifestyle intervention or metformin to manage diabetes - known as the Diabetes Prevention Program (DPP). Which outcome/intervention combination was most effective (as assessed at end of study on March 31, 2001)? Name the "outcome, intervention" Group of answer choices CVD, lifestyle CVD, placebo Diabetes, metformin Diabetes, lifestyle. Article:The average follow-up was 2.8 years. The incidence of diabetes was 11.0, 7.8, and 4.8 cases per 100 person-years in the placebo, metformin, and lifestyle groups, respectively. The lifestyle intervention reduced the incidence by 58 percent (95 percent confidence interval, 48 to 66 percent) and metformin by 31 percent (95 percent confidence interval, 17 to 43 percent), as compared with placebo; the lifestyle intervention was significantly more effective than metformin. To prevent one case of diabetes during a period of three years, 6.9 persons would have to participate in the lifestyle-intervention program, and 13.9 would have to receive metformin.Lifestyle changes and treatment with metformin both reduced the incidence of diabetes in persons at high risk. The lifestyle intervention was more effective than metformin.

Reference no: EM133868818

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