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Given the following data, assess whether human hematopoietic stem cells can truly self-renew in vivo. & About 400 billion mature hematopoietic cells are produced daily.
The best estimate of the Hayflick limit is 44 to 50.
About 1:5000 progenitors do NOT apoptose.
About 50 to 1000 mature cells are made per progenitor (6 to 10 doublings).
The entire differentiation pathway may be 17 to 20 doublings (soft fact).
About 10 to 30 million cells at most can be made from a highly purified single hematopoietic stem/preprogenitor cell in vitro.
Present order of magnitude calculations in constructing your decision. Also perform parameter sensitivity analysis of each of the parameters that govern the hematopoietic process. How important are the parameters that govern telemorase activity in determining the total number of mature progeny produced over a person's lifetime?
What does LD 50 mean in Industrial Toxicology and What is its significance to workers handling pesticides What units are used to quantify the standard service illuminance for specific work activities? Name the instrument used to appraise the lig..
One type of commercial smoke detector contains a minute amount of radioactive americium-241 (241Am), which decays by -particle production. The particles ionize molecules in the air,
An insulated cylinder fitted with a weightless latched piston contains steam at 5 bar, 300 °C. The piston is unlatched and the steam expands against ambient air at P = 1 bar. The temperature of steam in the final state is 142 °C. Determine the ene..
Estimate the density of air, If we approximate the atmosphere to be 79% nitrogen (N_2) by volume and 21% oxygen (O_2)
what drum speed in r/min is necessary to make the amount of filtrate delivered in 24 h from the rotary filter exactly equal to the maximum amount of filtrate obtainable per 24 h from the plate-and-frame filter?
Calculate the stoichiometric reactant ratio (mol H2 react/mol C2H2 react) and the yield ratio (k mol C2H6 formed/k mol H2 react).
Derive the following equation for the optimum outside diameter of insulation on a wire for maximum heat loss:
Is the proposed stead-state operation feasible - What is the corresponding length of wire that may be used in the heater for a maximum available voltage of 110V? What is the power rating of the heater?
(a) What is the minimum number of theoretical stages necessary to effect this separation? (b) What is the minimum extract reflux ratio?
Find the efficiency of the transformer for 70% full load at 230 V and 0.85 power factor.
Calculate the line voltage at the secondary terminals of the transformer if the load is disconnected from the transformer. Assume that the input voltage to the transformer remains unchanged. Neglect core loss and magnetizing current
The feed (CAo= 1.0, CRo= 0, CSo= 0) enters two mixed reactors in series (?1= 2.5 min,?2= 10 min) knowing the composition in the first reactor (CA1= 0.4, CR1= 0.4, CS1= 0.2),find the composition leaving the second reactor (using fractional yield co..
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