Determine how each component interacts

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Reference no: EM133583843

Question: You have recently discovered the signalling pathway underlying locomotory activity patterns in the nematode worm C elegans. These patterns involve alternating times of high activity levels and low activity levels. You have identified the signalling pathway that controls these oscillating activity levels; it can be reduced to a model network described by three interacting components (A, B, and C). You know nothing about A, B, and C, other than their interactions are required for the observed activity patterns. So, you set out to determine how each component interacts with the others (i.e. how do A, B, and C influence one other to generate these oscillations).

You are able to reduce the number of hypotheses to the following list:
1. A inhibits B, B inhibits C, and C inhibits A
2. A inhibits B, B inhibits C, and C activates A
3. A activates B, B activates C, and C inhibits A
4. A inhibits B, B activates C, and C activates A
5. A activates B, B inhibits C, and C activates A

This simulator allows you to test your hypotheses. Note that the simulator gives you access to a sensitivity parameter, the degradation rates for A, B, and C, and the ability to hold A constant at different concentrations (i.e. the CLAMP feature, that you can turn ON and OFF by setting the parameter ON=1 or OFF=O).

Be sure to SELECT the LAST DIGIT of your student number in the appropriate box to initialize the simulator for all your experiments, before pressing RUN.

Use an experimental approach to determine which of the original five hypotheses listed above is most likely to be true. Copy-paste the appropriate hypothesis from.

Reference no: EM133583843

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