Design a process using superpro designer

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Reference no: EM133851986

Set up a process entailing the production of biomass in two steps:

1. Glucose (15 kg) and water (5000 kg/h) at 25°C and 1 atm are mixed in a blending tank. The mixture is agitated for 15 minutes and heated to 37°C (1°C/min). The contents (culture medium) are then transferred out to the bioreactor.

2. Once the transfer is completed, biomass is inoculated at 1 kg cells/batch. The cells grow following Monod kinetics with μ_max = 0.01 1/h and K_s = 0.05 mg/L of substrate.

Assume that the bioreaction can be represented by the following:

7 Glucose + 18 O₂ -> 9 Biomass + 10 CO₂ + 6 H₂O (mass coefficients)

a. Set up this as a batch process. Graph the profiles of glucose, biomass, and 02 over time.

b. Introduce a schedule for the process

c. Modify part (b), for a fed-batch process for (i) constant glucose or (ii) 02.

List your assumption (e.g., for flow rates etc.).

Your solution should be submitted as a .SPF (SuperPro Designer) file of the process. Al- so provide Excel spreadsheet files generated using SPD, for the profiles in parts (A) and (B).

Question 1: Design a process using SuperPro Designer to generate poliovirus in cell culture. This is a two-step process: First, cells are grown for 96 hours, and then infected with po¬liovirus, leading to its proliferation. A relevant mathematical model is included in the article 'Kinetic model for adherent Vero cell growth and poliovirus production in batch bioreactors' by Y. Jiang et al., Process Biochemistry, 81: 156-64, 2019. Get expert online assignment help in the USA now!

Your process does not have to replicate precisely the one described in the article. To keep the process simple, you may assume that the cells grow in suspension without mi¬crocarriers and use glucose as the main substrate. In addition to the SPD file, you should provide an Excel file with the profiles of glucose (substrate), cells and viral particles with time. Clearly state your assumption.

Reference no: EM133851986

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