Cyclosporine comes to office due to nausea and anorexia

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Reference no: EM133858957

Question

A 43-year-old kidney transplant patient treated with cyclosporine comes to the office due to nausea and anorexia. The patient underwent transplantation seven months ago and had been doing well until recently. On examination, his blood pressure is 159/97 mm Hg. There is no tenderness at the site of the transplanted kidney. Serum creatinine is 4.1 mg/dL, and the serum cyclosporine level is markedly increased. Two weeks ago, he had normal blood pressure and normal levels of cyclosporine and serum creatinine. Further questioning reveals that the patient has been drinking increased amounts of grapefruit juice lately as part of an attempt to improve his overall health. Which of the following mechanisms is most likely responsible for this patient's current condition?

1) Enhances gastric acidity 2) Inhibition of cytochrome P450 enzymes 3) Inhibition of transmembrane drug transport 4) Reduction of plasma protein binding

Reference no: EM133858957

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