Asthmatic response is phase of acute bronchoconstriction

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Reference no: EM133876652

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Shorten "The early asthmatic response is a phase of acute bronchoconstriction that reaches a maximum in the first 30 minutes and resolves within 1 to 3 hours. During the early asthmatic response, antigen exposure to the bronchial mucosa activates dendritic cells to present the antigen to T helper cells (CD4+ T cells), which differentiate into Th2 cells releasing numerous inflammatory cytokines (Box 36.1). Together, these mediators activate inflammatory cells and cytokines, resulting in vasodilation, increased capillary permeability, mucosal edema, bronchial smooth muscle contraction (bronchospasm), and tenacious mucus secretion from mucosal goblet cells with narrowing of the airways and obstruction to airflow.

Reference no: EM133876652

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