Apeced lack expression of the aire protein

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Reference no: EM133635685

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Individuals with an inherited form of autoimmunity known as APECED lack expression of the AIRE protein. About one-third of these individuals develop type 1 diabetes, a disease caused by autoimmune destruction of the insulin-producing cells in the pancreas. Based on this, what is one function of the AIRE protein? to induce the transcription of FoxP3 in peripheral self-reactive T cells that encounter their self antigen to neutralize autoantibodies and prevent their binding to insulin-producing cells in the pancreas to induce deletion of pancreas antigen-specific B cells during their development in the bone marrow to interfere with CD80/CD86 up-regulation on antigen-presenting dendritic cells in the pancreas to induce transcription of insulin-producing pancreatic self antigens in the thymus.

Reference no: EM133635685

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