Antibody deficiency diseases

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Reference no: EM134020163

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In a class of antibody deficiency diseases, developing B cells from the bone marrow of several patients were isolated and stimulated through their B-cell receptors. Analysis of the stimulated cells showed normal tyrosine phosphorylation of Igα and Igβ and normal recruitment and activation of Syk. Yet, no activation of PLC-γ, no actin polymerization, and no activation of the integrin LFA-1 could be observed after stimulating the antigen receptor on the patients' cells. Which of the following proteins might be encoded for by a candidate gene in this immunodeficiency?

Reference no: EM134020163

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