Study of asian chinese of normal range of waveform indices, Biology

A Collective Study performed on Asian Chinese Normotensive Population to Obtain Healthy Normal Range of some Waveform Indices 

Background- Arterial blood pressure waveforms contain rich pathophysiological information of the cardiovascular system where they are more than just numerical digits of indices.  This information includes indices describing left ventricular systolic function and arterial properties such as the conventional systolic blood pressure (SBP), diastolic blood pressure (DBP) and pulse rate (PR) which have been validated with a set of range as a guide to aid monitoring of the blood pressure. Fiducial points of arterial blood pressure waveforms such as the onsets, systolic peaks and dicrotic notches are important points of the arterial blood pressure waveform and such information would serve as a better reflect one's health condition. Thus with these information, a new set of additional indices such as central aortic systolic pressure (CASP), systolic upstroke gradient (SUG), systolic cycle  and ratio of net area (RNA) may serve a basis of assessment of one's health.   

Methods and Results- We conducted a study using BPro®, a validated US FDA (510k no.: k060315) approved device, which is connected to a laptop with an A-PULSE CASP software that has been clinical validated and approved by the regulatory authorities, US FDA (510k no. : k072593). A total of 2157 Asian subjects comprising of 1036 females and 1121 males participated in this study. The subjects were drawn from Singapore and China provinces such as  Beijing, Shanghai and Xi An. With the collected data,  simple scatter plots of the distribution of the various indices for normotensive people were drawn across the age group. After which, linear equations  were  determined using linear regression analysis and 95% confidence interval denoting the reference range for normotensive population for the various indices. These graphs were plotted using SPSS 13.0 and Microsoft Office Excel 2003.  

Conclusions- The ability to express waveform indices in terms of numbers not only aid in the determination of the effects of drugs and other interventions, reference ranges and trends have been generated to monitor and aid in improving the quality of our health. Through this study, we highlight CASP, SUG, systolic cycle and RNA with brief analysis and their reference ranges. Currently, there has  already  been a shift to include CASP measurements and reference ranges in a few guidelines for hypertension. Hence, it is hoped that more outcome studies and trials may be conducted to seek greater relevance and correlations of these waveform indices to our health. Therefore in future, we seek to attach weightage to these waveform indices to generate a composite index. And with this impactful composite index comprising of all the important indices, we are able to obtain a more accurate indicator of our cardiac health. 

Posted Date: 9/25/2012 6:19:19 AM | Location : United States







Related Discussions:- Study of asian chinese of normal range of waveform indices, Assignment Help, Ask Question on Study of asian chinese of normal range of waveform indices, Get Answer, Expert's Help, Study of asian chinese of normal range of waveform indices Discussions

Write discussion on Study of asian chinese of normal range of waveform indices
Your posts are moderated
Related Questions
Define General Purpose and Specialized Culture Media? General purpose media - These support the growth of many microorganisms. Example: nutrient agar, trypic soy agar etc. S

Q. What are the functions of the spleen? Why is a total splenectomy (surgical removal of the spleen) compatible with life? The spleen has many functions: it participates in the

A healthy, primiparous (first-time) mother delivered a healthy infant several hours ago, but the mother has experienced postpartum hemorrhage. Which of the following disorders is m

How do biodiversity, the total number of living beings and the biomass respectively vary during the ecological succession? Biodiversity, the number of living beings and the bio

Q. Fats requirement in pectic ulcer? Fats: These delay the gastric emptying. The products of fat digestion in the small intestine stimulate entrogastrone, which inhibits gastri

Define Regents for Estimation of Vitamin C - Colorimetric Method? 1. 2, 4 dinitrophenylhydrazine reagent - Dissolve 2 g of dinitrophenyl hydrazine in 100 ml of 9N sulphuric aci

Which type of defense cell do bacteria attract and cause to multiply during the inflammation process? What is the name given to the waste material produced by the inflammation trig

Explain the Kidney Structure in human biology? The body's two kidneys are located in the small of the back, one behind the stomach and one behind the liver. Each kidney is comp

In genetic recombination by crossing over what is the difference between parental gametes and recombinant gametes? The Parental gametes are those gametes that maintain the orig