Multicausal nature of cancer, Biology

Multicausal Nature of Cancer

With several dividing cells in the organism and the various proto-oncogenes and tumor suppressor genes that can be changed to cause cancer. one might expect cancer to be a more common event than it is. Several biologists believe that probably our/body has many initiated cells acquired throughout our life time but the several defense mechanisms of the body destroy them before they can cause cancer. Increasing proof now suggests that any single mutation in a cell is never by itself enough to cause cancer. Just only when a single cell suffers several sequential mutations does it lastly lose its regulation over its cell cycle and a fully fledged cancer results. One of the diseases which explains this concept is colorectal cancer. Primarily, in normal epithelium a suppressor gene on chromosome 5 is inactivated or lost. Next comes hypomethylation of DNA that is followed by mutation of ras proto-oncogene.

The losses of chromosomes 18 and 17 whole the transformation into a cancer cell. Further chromosome losses give the tumor the ability to form metastases. More and more research is being done on what in fact activates or turns on the genes in tumor cells and the role that individual oncogenes play in making the cells cancerous. By comparing DNA sequences of known oncogenes along with genes for cell growth and growth receptors, investigators have begun to identify key genes. For instance, an oncogenes has been found to correspond to the gene that functions as a growth factor in the healing of wounds. The invention of newer oncogenes is leading towards a better understanding of normal cell growth pathways and as well the-role of proto-oncogenes in development processes. The current efforts in prevention and treatment of cancers are characterized via a multidisciplinary approach. Early detection and characterization of the tumor is an important prerequisite for effective treatment. Understanding the cellular and molecular aspects of growth, differentiation and neoplastic change will provide clues to development of effective drugs for treatment. The combined efforts of developmental biologists and medical scientists can eventually lead to alleviation of human suffering from the disease.

Posted Date: 1/31/2013 7:51:28 AM | Location : United States







Related Discussions:- Multicausal nature of cancer, Assignment Help, Ask Question on Multicausal nature of cancer, Get Answer, Expert's Help, Multicausal nature of cancer Discussions

Write discussion on Multicausal nature of cancer
Your posts are moderated
Related Questions
In this session's discussion board provide links to the nutrition information for 2 products. The nutrition information should be the type you find on the side of a food product th

Identify the signs and symptoms associated with death from mercury. Explain Please.

Would you expect the muscle fibers of the tongue to be striated or smooth? What about the muscle of the diaphragm/ Explain your answer.

Anticodon is the series of three nucleotides on the transfer RNA molecule which recognizes and pairs with the specific codon on a messenger RNA molecule; it helps in controlling t

The axons of all the baroreceptors in the body were destroyed at 2 AM.  All else is normal.  Which of the following statements is true for the system at 2:10 AM when compared to th

I stored a few of my things from April to September this year. When I wanted to unpack the boxes, I found hundreds of round, small, black things. They look like they might be snail

The Period of Persecution: Earlier. treatment of  the  inentally sick depended on men's various superstitious beliefs.  It was thought that sounds and motions are  the factors

What is photoperiodism? Photoperiodism is the biological response shown by some living beings to their daily time of light exposure (photoperiod).

Q. Atrial Fibrillation or Flutter? Transient atrial fibrillation or flutter is seen frequently and can be associated with CAD, rheumatic heart disease, thyrotoxicosis, or myoc

Are dogs colour blind