Multicausal nature of cancer, Biology

Multicausal Nature of Cancer

With several dividing cells in the organism and the various proto-oncogenes and tumor suppressor genes that can be changed to cause cancer. one might expect cancer to be a more common event than it is. Several biologists believe that probably our/body has many initiated cells acquired throughout our life time but the several defense mechanisms of the body destroy them before they can cause cancer. Increasing proof now suggests that any single mutation in a cell is never by itself enough to cause cancer. Just only when a single cell suffers several sequential mutations does it lastly lose its regulation over its cell cycle and a fully fledged cancer results. One of the diseases which explains this concept is colorectal cancer. Primarily, in normal epithelium a suppressor gene on chromosome 5 is inactivated or lost. Next comes hypomethylation of DNA that is followed by mutation of ras proto-oncogene.

The losses of chromosomes 18 and 17 whole the transformation into a cancer cell. Further chromosome losses give the tumor the ability to form metastases. More and more research is being done on what in fact activates or turns on the genes in tumor cells and the role that individual oncogenes play in making the cells cancerous. By comparing DNA sequences of known oncogenes along with genes for cell growth and growth receptors, investigators have begun to identify key genes. For instance, an oncogenes has been found to correspond to the gene that functions as a growth factor in the healing of wounds. The invention of newer oncogenes is leading towards a better understanding of normal cell growth pathways and as well the-role of proto-oncogenes in development processes. The current efforts in prevention and treatment of cancers are characterized via a multidisciplinary approach. Early detection and characterization of the tumor is an important prerequisite for effective treatment. Understanding the cellular and molecular aspects of growth, differentiation and neoplastic change will provide clues to development of effective drugs for treatment. The combined efforts of developmental biologists and medical scientists can eventually lead to alleviation of human suffering from the disease.

Posted Date: 1/31/2013 7:51:28 AM | Location : United States







Related Discussions:- Multicausal nature of cancer, Assignment Help, Ask Question on Multicausal nature of cancer, Get Answer, Expert's Help, Multicausal nature of cancer Discussions

Write discussion on Multicausal nature of cancer
Your posts are moderated
Related Questions
Q. What are the values of DPD for plant cells under hypertonic, hypotonic and isotonic media? In plant cells under hypertonic medium there is loss of water for the external, SF

Highlight ten applications of conductometry and explain four in detail

Tissue Level - Level of body organization As you know a tissue is a group of cells similar in origin and structure that perform a specific function. The next level, is the tis

What are the main structures of the human eye? The major structures of the human eye are the cornea, the iris, the pupil, the ciliary muscles, the crystalline lens and the ret

Phylum Rhodophyta (Red algae) 1) The photosynthetic pigments include red pigments (phycoerythrin) and blue pigment (phycocyanin) apart from chlorophyll, of which red pigment pr

The cell cycle undergoes a sequence of changes which involve a period of growth replication of DNA, Followed by cell division. This sequence of changes is called cell cycle.

Define Historical example of Ecosystems Science? Mathematical and statistical tools are central to enhancing our understanding of large-scale systems and contain, for instance,

Q. What are the classes into which the phylum Arthropoda is divided? What are the three major ones and some of their representative species? The three main classes of arthropod

Why are calcium carbonate and carbon dioxide and carbon monoxide considered inorganic compounds? "The name "organic" is a historical name, dating back to 19th century, when it

Formation of female gametes: Ovule develops from a cushion like part of the ovary called the PLACENTA. OvuleĀ is connected to the placenta by a stalk known as FUNICLE. The