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Adefovir dipivoxil (Hepsera)
This phosphonate nucleoside analog, administered as the oral prodrug, inhibits replication of HBV, including variants resistant to lamivudine. Adefovir treatment of HBeAg-positive or -negative chronic hepatitis B is associated with marked reductions in HBV DNA levels, aminotransferase normalization in 48% to 72% of patients, and histologic improvements in 53% to 64% at 48 weeks. More prolonged therapy results in higher rates of response; anti-HBeAg seroconversion occurs in 23% by 72 weeks. The antiviral effects of adefovir are similar in lamivudine-susceptible and -resistant HBV infections (MG Peters et al, Gastroenterology 2004; 126:91). Some experts recommend adefovir over lamivudine for long-term treatment of HBeAg-negative or cirrhotic patients because of the high risk of emergence of lamivudine resistance.
C ampylobacter infection C a mpylobacter jejuni is the commonest species found in poultry. These are delicate organisms that may not survive outside the host unless prot
Counselling a diabetic patient and their family members is very important as patient has to modify the life style and diet and needs family support. Therefore it is important for y
Q. What is extracellular digestion? Extracellular digestion is so that in which food breaking into utile molecules that can be internalized by the cell is done in the extracell
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The nominalists deny the existence of Plato's "types". For them only individuals exist. Species are man-made artificial abstractions. But naturalists, the biologists who have actua
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Open Pulmonary Valvotomy : Open pulmonary valvotomy by technique of inflow occlusion is done without cardio pulmonary bypass. Surface hypothermia is used and inflow occlusio
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