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Q. Define Hepatic Cholesterol Synthesis?
This is a highly complex process beginning with acetyl CoA formed from fatty acid oxidation or from carbohydrate breakdown. The rate-determining reaction, which is the conversion of hydroxy methyl glutaryl (HMG) CoA to mevalonate, is catalysed by the enzyme HMG-CoA reductase. It is the activity of this enzyme that largely determines the rate of cholesterol synthesis.
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