Zoonoses disease-transmissible spongif orm encephalopathies, Biology

Assignment Help:

Transmissible spongif orm encephalopathies


Transmissible spongiform encephalopathies (TSEs, also called Prion diseases) are fatal neurodegenerative diseases such as scrapie of sheep, Creutzfeldt-Jakob disease (CJD) of humans, bovine spongiform encephalopathy (mad cow disease) and chronic wasting disease (CWD) of deer and elk. Bovine Spongiform Encephalopathy is thought to be the cause of variant Creutzfeldt Jakob Disease (vCJD) which is a neurological disease different from CJD, leading to death in humans. TSEs are caused by accumulation of prion protein, an abnormal form of protein found in humans and animals. Normal prion protein is expressed in a wide variety of tissues, but conversion of normal prion protein to the TSE form appears to be restricted primarily to cells of the nervous and lymphoid systems. In order to determine why some cell types are more resistant to TSE infection than others, scientists developed a tissue culture system that allows them to monitor both acute and persistent abnormal prion protein (PrP- res) formation. It has been demonstrated that while any cell type can make new PrP- res following exposure to TSE infectivity, only some cell types go on to become chronically infected and make PrP-res persistently. This suggests that there are cell- specific factors that determine the susceptibility of a cell to chronic TSE infection. These factors, once identified, could be useful in designing effective anti-TSE therapeutics.


Related Discussions:- Zoonoses disease-transmissible spongif orm encephalopathies

What is prevailing wind direction, What is the prevailing wind direction in...

What is the prevailing wind direction in equatorial regions affected by the trade winds? a) The wind blows from east to west b) the wind blows from west to east.

Explain the fermentability or degradability, Explain the Fermentability or ...

Explain the Fermentability or Degradability? As you are aware that colon contains over 400 known species of bacteria that exist in a symbiotic relationship with the host. All f

Write a short note on muscular system, Write a short note on muscular syste...

Write a short note on muscular system? The muscular system provides mobility and support to the body. There are three types of muscle tissue: skeletal, smooth, and cardiac. Th

Classification of protein based on shape, Protein Classification Based on S...

Protein Classification Based on Shape There are three types of proteins on the basis of shape - Fibrous, Globular, Intermediate 1 .       FIBROUS PROTEINS They ar

Keel, keel is the characteristic feature of flower of 1.tomato 2. tulip 3.u...

keel is the characteristic feature of flower of 1.tomato 2. tulip 3.ubdugifera 4.aloe

Algae, what are the characteristics of algae?

what are the characteristics of algae?

Latitudinal variations, Latitudinal Variations The latitudinal variatio...

Latitudinal Variations The latitudinal variation of temperature over the earth is the result of two main variables incoming solar radiation and the distribution of lan

How many sodium dodecyl sulfate dissolve in 80 mls, How many grams of sodiu...

How many grams of sodium dodecyl sulfate (mw = 288.37) would you dissolve in 80 mLs of water to make a 20% solution of SDS?

Explain the concept of atoms are associated, What is the logical order in w...

What is the logical order in which the concepts of atoms, molecules, cells... up to biosphere are associated? Atoms form molecules that structure cells that form tissues that f

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd