Zoonoses disease-transmissible spongif orm encephalopathies, Biology

Assignment Help:

Transmissible spongif orm encephalopathies


Transmissible spongiform encephalopathies (TSEs, also called Prion diseases) are fatal neurodegenerative diseases such as scrapie of sheep, Creutzfeldt-Jakob disease (CJD) of humans, bovine spongiform encephalopathy (mad cow disease) and chronic wasting disease (CWD) of deer and elk. Bovine Spongiform Encephalopathy is thought to be the cause of variant Creutzfeldt Jakob Disease (vCJD) which is a neurological disease different from CJD, leading to death in humans. TSEs are caused by accumulation of prion protein, an abnormal form of protein found in humans and animals. Normal prion protein is expressed in a wide variety of tissues, but conversion of normal prion protein to the TSE form appears to be restricted primarily to cells of the nervous and lymphoid systems. In order to determine why some cell types are more resistant to TSE infection than others, scientists developed a tissue culture system that allows them to monitor both acute and persistent abnormal prion protein (PrP- res) formation. It has been demonstrated that while any cell type can make new PrP- res following exposure to TSE infectivity, only some cell types go on to become chronically infected and make PrP-res persistently. This suggests that there are cell- specific factors that determine the susceptibility of a cell to chronic TSE infection. These factors, once identified, could be useful in designing effective anti-TSE therapeutics.


Related Discussions:- Zoonoses disease-transmissible spongif orm encephalopathies

Define prevention of idd - iodized salt distribution, Define Prevention of ...

Define Prevention of IDD - Iodized salt distribution? Many approaches to reduce iodine deficiency has been formulated. Some of these are reviewed herewith: Iodized salt dist

Explain the properties or characteristics of dietary fibre, Explain the pro...

Explain the properties or characteristics of dietary fibre? Significant properties / characteristics of dietary fibre that affects its role are: 1) Solubility in water 2)

Types of cell wall, TYPES OF CELL WALL Cell wall differentiated into th...

TYPES OF CELL WALL Cell wall differentiated into the following layers : 1. Primary Cell Wall       2. Secondary Cell wall             3. Tertiary Cell wall 1 .

Explain about hydroxyapatite coating, Hydroxyapatite coating Hydroxyapa...

Hydroxyapatite coating Hydroxyapatite coating has been recommended for clinical use. These implants are superior with respect to the degree and rate of fixation in the bone as

Parasitology, how trematodes/nematodes adapt to their parasitic mode of fee...

how trematodes/nematodes adapt to their parasitic mode of feeding

Define cellulose, Cellulose Cellulose is found in plants as microfibr...

Cellulose Cellulose is found in plants as microfibrils (2-20 nm diameter and 100-40,000 nm long). These form the structurally strong framework in the cell walls. Cellulose is

What is the route of nutrients after digestion, Q. From the intestinal lume...

Q. From the intestinal lumen through to the tissues - what is the route of nutrients after digestion? Monosaccharides, mineral salts, amino acids and water are absorbed by the

How common are coiled-coil motifs to each other, 1. Name four experimental ...

1. Name four experimental techniques to determine protein-protein interactions other than X-ray & NMR techniques. 2. How common are Coiled-coil motifs? Where are they found? Giv

Explain the nutritional role of minerals in foods, Nutritional and function...

Nutritional and functional role of minerals in foods Essential elements including the main elements and a number of trace elements fulfill various functions: as electrolytes, a

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd