Zoonoses disease-transmissible spongif orm encephalopathies, Biology

Assignment Help:

Transmissible spongif orm encephalopathies


Transmissible spongiform encephalopathies (TSEs, also called Prion diseases) are fatal neurodegenerative diseases such as scrapie of sheep, Creutzfeldt-Jakob disease (CJD) of humans, bovine spongiform encephalopathy (mad cow disease) and chronic wasting disease (CWD) of deer and elk. Bovine Spongiform Encephalopathy is thought to be the cause of variant Creutzfeldt Jakob Disease (vCJD) which is a neurological disease different from CJD, leading to death in humans. TSEs are caused by accumulation of prion protein, an abnormal form of protein found in humans and animals. Normal prion protein is expressed in a wide variety of tissues, but conversion of normal prion protein to the TSE form appears to be restricted primarily to cells of the nervous and lymphoid systems. In order to determine why some cell types are more resistant to TSE infection than others, scientists developed a tissue culture system that allows them to monitor both acute and persistent abnormal prion protein (PrP- res) formation. It has been demonstrated that while any cell type can make new PrP- res following exposure to TSE infectivity, only some cell types go on to become chronically infected and make PrP-res persistently. This suggests that there are cell- specific factors that determine the susceptibility of a cell to chronic TSE infection. These factors, once identified, could be useful in designing effective anti-TSE therapeutics.


Related Discussions:- Zoonoses disease-transmissible spongif orm encephalopathies

Causes of diabetic ketoacidosis, Q. Causes of Diabetic Ketoacidosis? Th...

Q. Causes of Diabetic Ketoacidosis? The causes of Diabetic Ketoacidosis (DKA) are the following: - Missing of insulin injection - Infection - Trauma (injury) - Myoc

How can a child become infected with gonorrhoea, How can a baby become infe...

How can a baby become infected with (a) gonorrhoea, (b) syphilis   (a)  During birth, a baby might be become infected with gonorrhoea bacteria as it passes by t

What do you mean by biodigester, Q. What do you mean by biodigester? A ...

Q. What do you mean by biodigester? A biodigester is equipment that produces hydrogen sulfide, carbon dioxide and fuel gases (biogases) like methane from organic material under

What do you mean by pelvic girdle, What do you mean by Pelvic Girdle? B...

What do you mean by Pelvic Girdle? Bones in vertebrates which connect the appendages on left and right side of the posterior appendicular skeleton to each other. Pelvic girdles

Taxonomy, what arachnid is beneficial

what arachnid is beneficial

Photosynthesis, how do i prove in a diagram that water is needed for photos...

how do i prove in a diagram that water is needed for photosynthesis

Sastry, he heartbeat begins with the depolarization of the

he heartbeat begins with the depolarization of the

Angiographic quantification, Angiographic Quantification Gr 1 - minimal...

Angiographic Quantification Gr 1 - minimal systolic jet, clears rapidly Gr 2 - partial RA opacification Gr 3 - Opacification of whole of RA GR4 - Opacification of

Radiant warmer, Radiant Warmer A radiant warmer is a device used to m...

Radiant Warmer A radiant warmer is a device used to maintain the body temperature of the newborn and thus play an essential role in influencing oxygen consumption, apnea and

Defects of heart, DEFECT S OF HEART 1 .      Blue Baby syndrome (Cya...

DEFECT S OF HEART 1 .      Blue Baby syndrome (Cyanosis) - Due to persisting foramen ovalis in atrial septum even after birth, the impure blood from right auricles comes to

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd