Zoonoses disease-transmissible spongif orm encephalopathies, Biology

Assignment Help:

Transmissible spongif orm encephalopathies


Transmissible spongiform encephalopathies (TSEs, also called Prion diseases) are fatal neurodegenerative diseases such as scrapie of sheep, Creutzfeldt-Jakob disease (CJD) of humans, bovine spongiform encephalopathy (mad cow disease) and chronic wasting disease (CWD) of deer and elk. Bovine Spongiform Encephalopathy is thought to be the cause of variant Creutzfeldt Jakob Disease (vCJD) which is a neurological disease different from CJD, leading to death in humans. TSEs are caused by accumulation of prion protein, an abnormal form of protein found in humans and animals. Normal prion protein is expressed in a wide variety of tissues, but conversion of normal prion protein to the TSE form appears to be restricted primarily to cells of the nervous and lymphoid systems. In order to determine why some cell types are more resistant to TSE infection than others, scientists developed a tissue culture system that allows them to monitor both acute and persistent abnormal prion protein (PrP- res) formation. It has been demonstrated that while any cell type can make new PrP- res following exposure to TSE infectivity, only some cell types go on to become chronically infected and make PrP-res persistently. This suggests that there are cell- specific factors that determine the susceptibility of a cell to chronic TSE infection. These factors, once identified, could be useful in designing effective anti-TSE therapeutics.


Related Discussions:- Zoonoses disease-transmissible spongif orm encephalopathies

Determine the uses of electrical recording - brain function, Determine the ...

Determine the uses of Electrical Recording - Brain function We can also learn about brain function by recording its electrical activity. In electroencephalography (EEG) and the

Sporotrichosis, Sporotrichosis Sporotrichosis is subacute or chronic i...

Sporotrichosis Sporotrichosis is subacute or chronic infectious disease caused by a dimorphic fungus, Sporothrix schenkii which occurs commonly in soil, wood and vegetation. T

Types of radiography, Types of Radiography: Positron Emission Tomogra...

Types of Radiography: Positron Emission Tomography  (PET) Uses high-energy physics and computer techniques to  study  lung function; useful for quantitative measurement

Phototropic curvature is the result of uneven distribution, Phototropic cur...

Phototropic curvature is the result of uneven distribution of : 1. Gibberellin 2. Phytochrome 3. Cytokinins 4. Auxin Auxin

Phylum protozoa, how conjugation takes place in paramecium

how conjugation takes place in paramecium

B -pleated sheets protein structure, β - Pleated Sheets In this in...

β - Pleated Sheets In this inter molecular hydrogen bonds are present Two or more polypeptide chains come together and from a sheet. Condensation in little. However

Osmosis: Hypertonic Solution, If a cell were placed in a hypertonic solutio...

If a cell were placed in a hypertonic solution what could it do to protect itself?

Explain database search, Database Search: Once an open reading frame or th...

Database Search: Once an open reading frame or the partial amino acid sequence has been pre-determined, the investigator compares sequence with others in the databases using a com

Genetic material, What is the central principle of molecular biology?

What is the central principle of molecular biology?

Explain about the adequate intake (ai), Explain about the Adequate Intake (...

Explain about the Adequate Intake (AI)? If sufficient data are not available to establish an EAR and hence RDA, the AI is derived instead. The AI is derived from observations o

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd