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Prostaglandins and the structurally associated molecules prostacyclins, leukotrienes and thromboxanes, are called as eicosanoids because they having 20 carbon atoms. These hormones are associativaly short-lived and thus act locally near to their site of synthesis in the body. They are derived from the common precursor arachidonate described in the figure. This polyunsaturated fatty acid is a derivative of linoleate .The Prostaglandins encourage inflammation, modulate synaptic transmission between nerve cells, and induce sleep. Whereas aspirin (acetylsalicylic acid) has been used for centuries to reduce inflammation, fever and pain, it was not until year of 1974 which John Vane discovered how aspirin works. Aspirin hold back the synthesis of prostaglandins by irreversibly inhibiting prostaglandin synthase. This enzyme catalyzes the first phase in the synthesis of prostacyclins and thromboxanes, prostaglandins.
Figure: Biosynthetic relationship of the eicosanoids.
Explain the role of cuvier in animal taxonomy? Cuvier (1769-1832) was critical of Lamarck's evolutionary concept which thereafter remained in oblivion for half a century. Cuvi
Pathophysiology Distension and damage of the respiratory bronchioles selectively occur. Opening develops in the walls of the bronchioles. and they become enlarged and conf
What is Dyslipidaemia ? The results of epidemiological studies, as well as trials with angiographic or clinical endpoints, confirm the importance of various lipid fractions in
Uses of modified starches in food and confectionery industries Visit a grocery shop and look out for products such as the instant desserts, jelly beans, salad dressings, tomato
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Illustrate the thin and think filaments in the muscle fiber A healthy skeletal muscle fiber is isolated and has no external forces on it. It has normal intracellular levels of
CRANIAL NERVES 12 pairs. Total weight 12 gms. Upto amphibian 10 pairs cranial nerves are present. 1, 2, 8, - sensory. 3, 4, 6, 11, 12, motor. 5, 7, 9, 10 - mixed. 3
Linkage of Health With Development Health, in its comprehensive or holistic sense, refers to the state of completephysical, mental, social and spiritual well being of a person.
It is defined as the total amount of heat produced, when unit mass/volume of the fuel has been burnt completely and the products have been cooled to room temperature (~ 15 0 C).
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