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Prostaglandins and the structurally associated molecules prostacyclins, leukotrienes and thromboxanes, are called as eicosanoids because they having 20 carbon atoms. These hormones are associativaly short-lived and thus act locally near to their site of synthesis in the body. They are derived from the common precursor arachidonate described in the figure. This polyunsaturated fatty acid is a derivative of linoleate .The Prostaglandins encourage inflammation, modulate synaptic transmission between nerve cells, and induce sleep. Whereas aspirin (acetylsalicylic acid) has been used for centuries to reduce inflammation, fever and pain, it was not until year of 1974 which John Vane discovered how aspirin works. Aspirin hold back the synthesis of prostaglandins by irreversibly inhibiting prostaglandin synthase. This enzyme catalyzes the first phase in the synthesis of prostacyclins and thromboxanes, prostaglandins.
Figure: Biosynthetic relationship of the eicosanoids.
Q. What are cerebrospinal and meninges fluid? Meninges are the membranes that protect and the enclose central nervous system (CNS). Cerebrospinal fluid is the fluid that separa
Sickling occurs in deoxyhemoglobin S, but not in oxyhemoglobin S. Oxyhemoglobin has a small hydrophobic \"pocket\" in a ß chain region located in the interior of the protein. In de
EGESTION To give out undigested food from alimentary canal. Faeces can remain in colon for 36 hrs. then moving into rectum by gastro-colic reflex. Faeces consists of 3
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In one year, a population size of 500 changed to 496. What is the per-capita rate of increase/decrease?
Define Termination phase - mechanism of protein synthesis? Termination: RNA polymerase recognizes the terminator, which results in no further nucleotides being incorporated and
full variation topic
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