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Prostaglandins and the structurally associated molecules prostacyclins, leukotrienes and thromboxanes, are called as eicosanoids because they having 20 carbon atoms. These hormones are associativaly short-lived and thus act locally near to their site of synthesis in the body. They are derived from the common precursor arachidonate described in the figure. This polyunsaturated fatty acid is a derivative of linoleate .The Prostaglandins encourage inflammation, modulate synaptic transmission between nerve cells, and induce sleep. Whereas aspirin (acetylsalicylic acid) has been used for centuries to reduce inflammation, fever and pain, it was not until year of 1974 which John Vane discovered how aspirin works. Aspirin hold back the synthesis of prostaglandins by irreversibly inhibiting prostaglandin synthase. This enzyme catalyzes the first phase in the synthesis of prostacyclins and thromboxanes, prostaglandins.
Figure: Biosynthetic relationship of the eicosanoids.
Hospitalization Hospitalization is stressful experience for children, adolescents and their families. It is an interruption of the child's active cycle of growth and deve
Defence mechanisms of the host The healthy animal is protected from pathogenic organisms present in the environment by virtue of the effective immune mechanism present from bi
Q. How Genes can be exchanged between chromatids? When two homologous chromosomes physically exchangecorresponding segments during prophase I of meiosis, geneticists call it cr
Explain about the Net Protein Ratio (NPR)? This method was introduced by Bender and Doell (1957) and is a modification of the PER method. In this method, an allowance is made f
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When do you use the term 2' carbon and when do you use 2 carbons on a molecular structure? I need examples please!
Determine about the Klove Grooved Pegboard Test The subject must place pegs shaped like keys into a board having recesses that are oriented in randomly varying directions. The
IMPLAN TA TIO N - Attachement of blastocyst on the endometrium of the uterus is called implantation. Generally it occurs 7th day after fertilisation. (6-10 days). Blas
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