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Prostaglandins and the structurally associated molecules prostacyclins, leukotrienes and thromboxanes, are called as eicosanoids because they having 20 carbon atoms. These hormones are associativaly short-lived and thus act locally near to their site of synthesis in the body. They are derived from the common precursor arachidonate described in the figure. This polyunsaturated fatty acid is a derivative of linoleate .The Prostaglandins encourage inflammation, modulate synaptic transmission between nerve cells, and induce sleep. Whereas aspirin (acetylsalicylic acid) has been used for centuries to reduce inflammation, fever and pain, it was not until year of 1974 which John Vane discovered how aspirin works. Aspirin hold back the synthesis of prostaglandins by irreversibly inhibiting prostaglandin synthase. This enzyme catalyzes the first phase in the synthesis of prostacyclins and thromboxanes, prostaglandins.
Figure: Biosynthetic relationship of the eicosanoids.
Overheating the bone and exerting too much pressure Minimal temperature elevation during surgical drilling of the bone is a key factor in atraumatic surgical technique. Bone ce
The arterial supply is by the right and left coronary arteries. In the event of sudden block of one artery the area of myocardium supplied by that artery undergoes infarction.
Explain about the Complete proteins? We now know that proteins are composed of amino acids and that proteins differ in their amino acid make-up. Proteins lacking in one or more
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Annuloplasty with a Ring : The lings commonly used are Carpentier- Edwards and Cosgrove's flexible half ring. The rings are C shaped and have incomplete circles to accommoda
Q. Define the Herbals? During the Middle Ages, following the decline of the Greek and Roman civilisations, little significant botanical progress was made. The early herbals (i.
Give two examples in each case of organs or tissues in which you would expect (a) meiosis, (b) mitosis to be taking place a) Meiosis is likely to
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What are the main components of the human skeleton?
Where in the cell can ribosomes be found? What is the main biological function of ribosomes? Ans) Ribosomes can be found free in the cytoplasm, adhered to the outer side of the
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