What is Pancreatic lipase

Pancreatic lipase  acts on  the dietary triacylglycerols after it has been incorporated into the mixed micelle  in  the  intestinal lumen. The lipase  acts at  interface between water and  the triacylglycerol molecules, and its catalytic action  is facilitated by  the presence  of  colipase  (a small protein cofactor needed  by  pancreatic  lipase for efficient dietary lipid hydrolysis), which is also produced by the pancreas. Pancreatic lipase is specific for the fatty acid residues at positions  1 and 3 of the glyceryl moiety thus releasing  2-monoacylglycerol and two  fatty acids  from a triacylglycerol molecule. The  final digestive products of  triacylglycerol digestion are free fatty acids, glycerol and monoacylglycerols.