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Intermittent Treatment
Intermittent 4-drug regimens with 2 or 3 doses per week after at least 2 weeks of daily therapy are also effective for treatment of TB and should always be given by DOT. Once-weekly continuation-therapy regimens including rifapentine (instead of rifampin), started after 2 months of standard initial therapy, may also be effective for susceptible TB (Tuberculosis Trials Consortium, Lancet2002; 360:528), but the optimal rifapentine dose is not clear, and these regimens have been associated with development of resistance. Intermittent treatment should never be used for treatment of drug-resistant TB
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