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a) Donald is a 50 year old male with a long history of bipolar disorder. He has been hospitalized three times in the last 8 months for manic episodes. He was just admitted to your impatient psychiatric ward because he was trying to get though the security gate at the Southwest Airlines terminal, demanding to catch a flight to the moon. As the polic approached him he started to take of his clothes and urinate on the floor. They could not understand him because he was talking and yelling very fast. His urine toxicology screen is positive for marijuana and his admission labs including liver function tests are normal. He clearly appears manic so you decide to start a mood stabilizer, Depakote in combination with an atypical anti-psychotic, Olanzapine. It's your first year as a psychiatry resident and you remember that Depakote is prescribed according to a patient's weight. Donald weighs 90 kg and you want to treat aggressively at 30 mg/kg/day. All daily dosages greater than 250 mg should be given either twice a day or three time a day. You want to keep it as simple for the patient as possible so you decide to give it twice a day, once in the morning and once at bedtime. If you divide the doses equally, what are his morning and bedtime doses?
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Why it was necessary to develop regulations on the preparation and sale?
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