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Valvular Heart Diseases
Normal heart valves function to maintain a uni-directional flow of blood through cardiac chambers. Two basic problems that compromise the normal function of the valves are stenosis and insufficiency. Stenosis is a thickening of valvular tissue. causing a narrowing of the valvular opening. Insufficiency refers to the inability of the valve to close completely, allowing blood to regurgitate.
Causes
Predominant causative factor is rheumatic fever.
Patients on HAART Rifamycins induce hepatic CYP3A4 enzymes and can accelerate metabolism of protease inhibitors and some non-nucleoside reverse transcriptase inhibitors (NNRTIs
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