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All the cells present in the body contain genes and an approach targeted to modulate the expression of genes is known as gene therapy. This novel approach has emerged by the end of 20th century and comes up with a promise of treating a large number of genetic disorders by ultimately modifying the gene expression (Jin et al, 2008). The two forms of gene therapy are somatic and germ line.
Somatic gene therapy: During this therapeutic approach, the genetic diseases are treated by inserting recombinant genes into non-reproductive or somatic cells. This kind of approach is limited to the patient and does not get transmitted to the future generations of. A normal copy of the malfunctioning gene is inserted into the mutant cells due to which an improvement in the disease phenotype is observed (Dorin, 1996). In the recent past, this technique has been found to be successful in case of familial hypercholesterolaemia and adenosine deaminase deficiency. For treating these disorders hepatocytes and T cells have been used for gene transfer respectively (Dorin, 1996). It has also shown significant success in case of cystic fibrosis and cancer. Various vehicles, like viral and non viral vectors help in the introduction of the genetic material into the mutated cells (Elias and Annas, N.D). This therapeutic approach is categorized into three sections:
However this approach produces short term results as the tissues die and get replaced with other cells.
What is the clinical manifestation of the disease known as daltonism? An X-linked daltonism is a disease in which the affected individual sees the red color as green or confoun
mechanisms of reciprocal inhibition
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Is it more indicated for a geneticist desiring to map the X chromosome of the mother of a given family (the researcher does not have access to her DNA, only access to the genetic m
The Red Data Book Species judged as threatened are listed by various agencies as well as by some private organisations. The most cited of these lists is the Red Data Book. It
Food Applications of Curdlan Curdlan has a variety of food applications as enumerated herewith: a) Meat and Poultry Curdlan makes meat and poultry products juicier and
what is the habitat of spongilla
Echocardiographic evaluation should be performed in all patients with clinically suspected IE, including those with negative blood cultures. Not only is TEE the preferred approach
Abdomen check the contour of the abdomen; normally it should be soft, symmetrical, slightly round and moves in synchronously with chest in premature neonate abdomen w
Cyanide - Enzyme-activity Control Plants generate cyanide from cyanogenic glucides and histidines. Ethylene biosynthesis is also accompanied by cyanide production. Nitrate red
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