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Sickle cell anaemia in man is caused by a defective chain of haemoglobin. The abnormal haemoglobin known as MbS differs from natural haemoglobin (HhA) in one amino acid. A substitutional mutation causes the replacement of glutamic acid by valine in the sixth position from the amino terminal end of the Q chain polypeptide. This is because instead of the triplet GAA or GAG which codes for glutarnic acid in normal chains, the abnormal mRNA has GUA or GUG which codes for valine. IdbS in deoxygenated state precipitates out of solution forming elongate crystals. 'The formation of crystals in turn produces a characteristic deformation of RBCs and the cells acquire a crescent or sickle shape, hence the name sickle cell anaemia. The deformation of red cell weakens the red cell membrane and lyses the cells. The loss of red cells and haemoglobin leads to anaemia and this causes oxygen deficiency to the tissues per unit time. Pt, single substitution, more specifically, replacing the thymine by adenine in the second position of the sixth triplet of the P chain gene triggers a variety of responses that affects several aspects of the pfnysiology of the organism. Individuals who are homozygous (HbSiHbS) for the gene usually die early in life. In heterozygotes some proporrion of red cells lyse periodically but this does not cause any serious harm to the individual and in any case the survival is not affected.
What is the life cycle type of bryophytes? As in all plants the life cycle of bryophytes is diplobiontic (alternation of generations). In bryophytes the lasting form is the hap
General characteristics of phylum
Indian tick typhus Indian tick typhus (Mediterranean spotted fever) is a tick-borne rickettsial infection caused by Rickettsia conori and is characterized by fever and a chara
Isonzerization of glucose-6-phosphate Isonzerization of glucose-6-phosphate : This step is catalyzed by phosphoglucoisomerase to form fructose-6-phosphate.
DEVELOPMENT OF GENETICS-A HISTORICAL PERSPECT As systematic study of genetics began, answers were sought to questions such as i) why are we like our parents? ii) why do org
Q. What is the name of the cells capable of making gametes? What is the ploidy of these gamete-forming cells? The cells that form gametes are the germ cells as opposed to the s
differenciate between plasma and serum
Q. Determine the acidity in the given sample of honey? This activity will help you to: • carry out the acidity test of the given samples of honey, • learn about the kee
What is the formula for calculation of bone distortion The following formula can be used to calculate for distortion: Effective Bone available = Reference sphere diameter ×
Which of the following best explains the reason why DNA ligase is needed to complete the replication of internal chromosomal segments? A. DNA ligase is able to delete the last
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