Already have an account? Get multiple benefits of using own account!
Login in your account..!
Remember me
Don't have an account? Create your account in less than a minutes,
Forgot password? how can I recover my password now!
Enter right registered email to receive password!
Sickle cell anaemia in man is caused by a defective chain of haemoglobin. The abnormal haemoglobin known as MbS differs from natural haemoglobin (HhA) in one amino acid. A substitutional mutation causes the replacement of glutamic acid by valine in the sixth position from the amino terminal end of the Q chain polypeptide. This is because instead of the triplet GAA or GAG which codes for glutarnic acid in normal chains, the abnormal mRNA has GUA or GUG which codes for valine. IdbS in deoxygenated state precipitates out of solution forming elongate crystals. 'The formation of crystals in turn produces a characteristic deformation of RBCs and the cells acquire a crescent or sickle shape, hence the name sickle cell anaemia. The deformation of red cell weakens the red cell membrane and lyses the cells. The loss of red cells and haemoglobin leads to anaemia and this causes oxygen deficiency to the tissues per unit time. Pt, single substitution, more specifically, replacing the thymine by adenine in the second position of the sixth triplet of the P chain gene triggers a variety of responses that affects several aspects of the pfnysiology of the organism. Individuals who are homozygous (HbSiHbS) for the gene usually die early in life. In heterozygotes some proporrion of red cells lyse periodically but this does not cause any serious harm to the individual and in any case the survival is not affected.
Define Spiral cleavage in brief. Pattern of cell division in the developing embryo where products of the cell divisions shift by rotating either counterclockwise or clockwise s
How can the concept of recombination frequency be used in genetic mapping? The Genetic mapping is the determination of the location of the genes in a chromosome. Besides determ
electron transport chain
Q. What are the two major divisions of the chordate phylum? Chordates are divided into vertebrates and protochordates (urochordates and cephalochordates). Q. What are the d
Explain the Biochemical Approach in Taxonomy Comparative biochemistry is being used increasingly in the systematic of animals, both for identification of organisms as well as f
Diagram the cross and determine which allele is dominant for each of the following Drosophila matings? a. Two red-eyed flies yield 110 red-eyed and 35 brown-eyed offspring.!
A healthy person is on a diet that consists of very small amounts of water. A. This person will have high water permeability across the luminal membranes of the medullary colle
Q. How is the yolk sac formed? What is the function of the yolk sac? The yolk sac is formed from the covering of the vitellus by few cells originated from the primitive gut.
what major nerve do you think is being compressed when a person often feel pain in the posterior surface of the thigh radiating to the area behind the knee and where is the likely
How is the striped pattern of the striated muscle cells formed? The functional units of the muscle fibers are the sarcomeres. Within the sarcomeres blocks of myosin and actin
Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!
whatsapp: +1-415-670-9521
Phone: +1-415-670-9521
Email: [email protected]
All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd