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Sickle cell anaemia in man is caused by a defective chain of haemoglobin. The abnormal haemoglobin known as MbS differs from natural haemoglobin (HhA) in one amino acid. A substitutional mutation causes the replacement of glutamic acid by valine in the sixth position from the amino terminal end of the Q chain polypeptide. This is because instead of the triplet GAA or GAG which codes for glutarnic acid in normal chains, the abnormal mRNA has GUA or GUG which codes for valine. IdbS in deoxygenated state precipitates out of solution forming elongate crystals. 'The formation of crystals in turn produces a characteristic deformation of RBCs and the cells acquire a crescent or sickle shape, hence the name sickle cell anaemia. The deformation of red cell weakens the red cell membrane and lyses the cells. The loss of red cells and haemoglobin leads to anaemia and this causes oxygen deficiency to the tissues per unit time. Pt, single substitution, more specifically, replacing the thymine by adenine in the second position of the sixth triplet of the P chain gene triggers a variety of responses that affects several aspects of the pfnysiology of the organism. Individuals who are homozygous (HbSiHbS) for the gene usually die early in life. In heterozygotes some proporrion of red cells lyse periodically but this does not cause any serious harm to the individual and in any case the survival is not affected.
Why is the fish circulation classified as a simple and complete circulation? Complete circulation is that in which there is no mixture of venous blood and arterial blood. As ci
If water dousing, homeopathic cures, and so on work for just me but not for anyone else, it is still science.
Considering the hybridization in a trait like the color of the flowers of a given plant species (red/yellow) conditioned by a pair of different alleles in relation to complete domi
WHAT IS THE CLASSIFICATION OF PROTOZOA ..
Which two gases are exchanged when living organisms breathe? Oxygen and carbon dioxide are the gases exchanged when living organisms breathe.
Q. What are the major proteins that constitute the sarcomere? What is the function of those molecules in the muscle cells? In the sarcomere there are organized myosin and actin
The major factor which controls glycogen metabolism in the liver is the concentration of phorphorylase alpha. Certainly, this enzyme catalyzes the limiting step of glycogen breakdo
Are the following statements true for eukaryotes , prokaryotes, both groups, or neither group? Answer They use a deoxyribonucleoside triphosphate as their energy currency"D They us
Metestrus - Estrous cycle This occurs shortly after ovulation and is intermediate between estrus and diestrus. The period lasts for 10 to 14 hours and mating is usually not perm
Define the Absorption of Vitamin A? Vitamin A and carotenoid tend to aggregate with lipids into globules, which then pass into the small intestine. Dietary vitamin A (retinol)
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