Already have an account? Get multiple benefits of using own account!
Login in your account..!
Remember me
Don't have an account? Create your account in less than a minutes,
Forgot password? how can I recover my password now!
Enter right registered email to receive password!
Sickle cell anaemia in man is caused by a defective chain of haemoglobin. The abnormal haemoglobin known as MbS differs from natural haemoglobin (HhA) in one amino acid. A substitutional mutation causes the replacement of glutamic acid by valine in the sixth position from the amino terminal end of the Q chain polypeptide. This is because instead of the triplet GAA or GAG which codes for glutarnic acid in normal chains, the abnormal mRNA has GUA or GUG which codes for valine. IdbS in deoxygenated state precipitates out of solution forming elongate crystals. 'The formation of crystals in turn produces a characteristic deformation of RBCs and the cells acquire a crescent or sickle shape, hence the name sickle cell anaemia. The deformation of red cell weakens the red cell membrane and lyses the cells. The loss of red cells and haemoglobin leads to anaemia and this causes oxygen deficiency to the tissues per unit time. Pt, single substitution, more specifically, replacing the thymine by adenine in the second position of the sixth triplet of the P chain gene triggers a variety of responses that affects several aspects of the pfnysiology of the organism. Individuals who are homozygous (HbSiHbS) for the gene usually die early in life. In heterozygotes some proporrion of red cells lyse periodically but this does not cause any serious harm to the individual and in any case the survival is not affected.
Define some Precautions for spore staining in a given bacterial culture? 1. Do not allow malachite green to dry on slide. 2. Decolourization should be done only after coolin
Q. Basic principles of planning diets for diabetes? The above objectives can be met by adhering to some of the basic principles of planning diets which include the consideratio
State the Lantern Test The patient names colours displayed in the lantern and the mistakes are analyzed. This is not the best method of testing because it depends on the natu
Q. How many are the well-known amino acids that form proteins in living beings? There are twenty different known amino acids that form proteins related to the genetic code of t
If dimples may be considered a single-gene dominant trait, and 64% of the population features dimples, calculate the frequencies of heterozygotes and both types of homozygotes, ass
allosteric regulation project idea
Animal Diseases - Diseases are common in domestic animals. Common signs of illness in animals are - 1. Cessation of rumination. 2. Drop in milk yield. 3.
Q. Define osseointegration and its theories? Osseointegration implies that "it is a contact established without interposition of non bony tissue between normal remodeled bone a
General characteristics of phylum
Subphylum Sarcodiha Pseudopodia typically present; flagella present in developmental stages of some species; free living or parasitic. Superclass - Rhizopoda Loc
Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!
whatsapp: +1-415-670-9521
Phone: +1-415-670-9521
Email: [email protected]
All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd