Renin-angiotensin system, Biology

Assignment Help:

As heart failure sets in, there is activation of RAS (Fig 2.1). Adrenergic stimulation of beta-1 receptors in juxtaglomerular apparatus of the kidneys results in release of renin. Another mechanism i.e. responsible for renin release is baroreceptor stimulation in renal vascular bed by reduction of renal blood flow.  

Angiotensin II that is released is a powerful vasoconstrictor and stimulates the release of aldosterone. It also causes remodeling of cardiac myocytes. Aldosterone retains sodium and has direct effects on myocardium. The result is increased systemic vascular resistance and development of edema. Hence the interruption of this renin-angiotensin-aldosterone axis by angiotensin-converting enzyme inhibitors (ACE-Inhibitors) or angiotensin receptor blockers (ARBs) has salutary effects as there is reduction in systemic vascular resistance, afterload reduction, mild diuresis and improvement in the cardiac output.

Angiotensin II also has direct role in modifying the structure and function of myocardium.

2243_Renin-Angiotensin System.png


Related Discussions:- Renin-angiotensin system

How does temperature affect the action of enzymes, How does temperature aff...

How does temperature affect the action of enzymes upon their substrates? There are explained temperature ranges under which enzymes operate and there is a specific temperature

Loudness, The sound levels of power, intensity and pressure are the physica...

The sound levels of power, intensity and pressure are the physical effects which the human ear receives, it is not, however, what the person perceives. What is being perceived or h

What are the main components of the cytoskeleton, The cytoskeleton is a net...

The cytoskeleton is a network of very little tubules and filaments spread throughout the cytoplasm of eukaryotic cells. It is made of microtubules, microfilaments and intermediate

Define food intake and energy requirements for humans, Define Food Intake a...

Define Food Intake and Energy Requirements for Humans? Many studies have shown that the subjects loose significant amounts of body mass; fat mass, as well as, fat free mass du

Examine the cysticerus larva under the microscope, Examine the cysticerus l...

Examine the cysticerus larva under the microscope? Examine the cysticerus larva under the microscope and note the following: i)  Bladder worm consists of a single layered, l

Clinical features - rheumatic fever, The American Heart Association (AHA) h...

The American Heart Association (AHA) has recommended the revised Jones Criteria as a guide for ARF diagnosis. The same have been approved by WHO study group for the diagnosis of in

What are typical fauna of the tropical forests, What are the typical vegeta...

What are the typical vegetation and the typical fauna of the tropical forests? In the vegetation of a tropical forest broadleaf evergreen trees predominate. On the top of the t

Nutritional deficiency, Iron deficiency should be treated with supplemental...

Iron deficiency should be treated with supplemental iron. • Osteoporosis should be treated with calcium and vitamin D supplements. • Depending on individual factors, patien

Define foam spray drying method, Define Foam Spray Drying Method? This...

Define Foam Spray Drying Method? This is an extension of spray drying and involves the use of gases dissolved under pressure prior to spraying. The main advantage is that the

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd