Renin-angiotensin system, Biology

Assignment Help:

As heart failure sets in, there is activation of RAS (Fig 2.1). Adrenergic stimulation of beta-1 receptors in juxtaglomerular apparatus of the kidneys results in release of renin. Another mechanism i.e. responsible for renin release is baroreceptor stimulation in renal vascular bed by reduction of renal blood flow.  

Angiotensin II that is released is a powerful vasoconstrictor and stimulates the release of aldosterone. It also causes remodeling of cardiac myocytes. Aldosterone retains sodium and has direct effects on myocardium. The result is increased systemic vascular resistance and development of edema. Hence the interruption of this renin-angiotensin-aldosterone axis by angiotensin-converting enzyme inhibitors (ACE-Inhibitors) or angiotensin receptor blockers (ARBs) has salutary effects as there is reduction in systemic vascular resistance, afterload reduction, mild diuresis and improvement in the cardiac output.

Angiotensin II also has direct role in modifying the structure and function of myocardium.

2243_Renin-Angiotensin System.png


Related Discussions:- Renin-angiotensin system

Sex-influenced traits, what are the examples of sex-influenced traits in hu...

what are the examples of sex-influenced traits in human?

What does an anther have on it, What does an anther have on it? The ant...

What does an anther have on it? The anther is the part of the flower that keeps the pollen. This and the filament both make up the stamen.

Response to flooding, Response to Flooding Prolonged flooding or water...

Response to Flooding Prolonged flooding or water-logging creates anaerobic conditions for the sub-surface parts of the plant and synthesis of alcohol dehydrogenase (ADH) helps

Define the historical process of spatial processes, Define the Historical P...

Define the Historical Process of Spatial processes? In year 1952 Alan Turing developed his theory of the generation of pattern in systems of reaction diffusion equations, now k

What do you mean by nervous system, Q. What do you mean by Nervous System? ...

Q. What do you mean by Nervous System? Structural Organization:   CNS + PNS Functional Organization:   only concerned with PNS Sensory (Afferent) ->  CNS Motor (Effe

Magnesium - mineral elements, Magnesium -  It is available in most of t...

Magnesium -  It is available in most of the plants, especially vegetables. By its deficiency diarrhoea is caused. Its important functions are - (a)      Along with c

Organic molecules, Organic Molecules Some organic molecules in life...

Organic Molecules Some organic molecules in life are Carbohydrates and Lipids à C, H and O Proteins à C, H, O, N & sometimes S Nucleic acids à C, H, O, N & P

Explain the term light reflex - neuronal pathways, Explain the term Light r...

Explain the term Light reflex - Neuronal pathways The neuronal pathway for light reflex can be afferent and efferent. In the afferent pathway, the pupillary fibres begin in the

Ecosystem and environment, How ecosyestem concept is useful to the study of...

How ecosyestem concept is useful to the study of environment?

Criminal Justice, AYou are a sergeant in a community relations unit in a mi...

AYou are a sergeant in a community relations unit in a mid-sized metropolitan police department. Your division commander sent you off to a 1-week ethics school run by the Justice D

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd