Renin-angiotensin system, Biology

Assignment Help:

As heart failure sets in, there is activation of RAS (Fig 2.1). Adrenergic stimulation of beta-1 receptors in juxtaglomerular apparatus of the kidneys results in release of renin. Another mechanism i.e. responsible for renin release is baroreceptor stimulation in renal vascular bed by reduction of renal blood flow.  

Angiotensin II that is released is a powerful vasoconstrictor and stimulates the release of aldosterone. It also causes remodeling of cardiac myocytes. Aldosterone retains sodium and has direct effects on myocardium. The result is increased systemic vascular resistance and development of edema. Hence the interruption of this renin-angiotensin-aldosterone axis by angiotensin-converting enzyme inhibitors (ACE-Inhibitors) or angiotensin receptor blockers (ARBs) has salutary effects as there is reduction in systemic vascular resistance, afterload reduction, mild diuresis and improvement in the cardiac output.

Angiotensin II also has direct role in modifying the structure and function of myocardium.

2243_Renin-Angiotensin System.png


Related Discussions:- Renin-angiotensin system

Describe prostaglandin-availability administration and alter, Describe Pros...

Describe Prostaglandin - Availability, Administration and Alternatives ? Prostaglandin El (available in India as Prostin VR, Pharmacia) is a very essential drug and should be a

Signs and symptoms diabetic ketoacidosis, Q. Signs and Symptoms diabetic ke...

Q. Signs and Symptoms diabetic ketoacidosis? The following are the signs and symptoms of DKA: 1) Increased heart rate (tachycardia) 2) Low blood pressure 3) Dehydratio

Explain clinical stigmata of syndromes in heart disease, Explain Clinical s...

Explain Clinical stigmata of specific syndromes in heart disease? Clinical stigmata of specific syndromes: Evidence of preseilce of chromosoinal anomalies or other syndromes

Conditions necessary for outbreak in salmonellosis, Q. Conditions Necessary...

Q. Conditions Necessary for Outbreak in salmonellosis? The food must contain or become contaminated with the Salmonella bacteria. These bacteria must be there in considerable n

Impact of technological change on the cost of health service, Impact of Tec...

Impact of Technological Change on the Cost of Health Service Technological developments entail improvement in production/service frontiers either by providing cost benefit adv

Explain about the net protein ratio (npr), Explain about the Net Protein Ra...

Explain about the Net Protein Ratio (NPR)? This method was introduced by Bender and Doell (1957) and is a modification of the PER method. In this method, an allowance is made f

Anomalies related to oral cavity, Anomalies Related to Oral Cavity   Un...

Anomalies Related to Oral Cavity   Under these anomalies we will briefly discuss the cleft lip and cleft palate.  You must have seen and/or nursed a baby born with a cut on

Rotential complications of post removal, Rotential complications of post re...

Rotential complications of post removal -Fracture of the tooth , -leaving the tooth unrestorable , or restored with fair prognosis -root perforation , -post breakage, and -

Unicellular organisms, How was it proved in the case of Amoeba that the key...

How was it proved in the case of Amoeba that the key to the life of a cell is Nucleus?

Explain about oil-bearing fruits, Explain about Oil-bearing fruits Oil-...

Explain about Oil-bearing fruits Oil-bearing fruits, nuts and seeds have been grown and used for food for many centuries. More than 100 varieties of plants are known to have oi

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd