Original hodgkin-huxley model, Mechanical Engineering

Assignment Help:

1. Plot the functions x1 and x as functions of voltage

2. Assume that you hold the membrane potential V at -120 mV until the system reaches equilibrium (i.e. until dx=dt = 0, where x = (V;m; h; n; a; b;M;H)T ) and that at time t = 0 you suddenly change and hold the value of the membrane potential at a value Vo. Plot the currents IL, INa, IK, IA, ICaT as well as the total current as functions of time for a number of di erent values Vo of you choice in the range -75 to +40 mV.

3. Write an algorithm for numerically approximating the solution to the above model.

4. Using the algorithm you developed in Question 2, illustrate the presence of post-inhibitory rebound (PIR) in the above model.

5. Using the algorithm you developed in Question 2 and assuming that ICaT is completely blocked (i.e. GCaT = 0), construct the gain function of the above model.

6. How does the gain function you constructed in Question 5 di er from the gain function of the original Hodgkin-Huxley model?


Related Discussions:- Original hodgkin-huxley model

Determine the net rate of work output, A piston and a cylinder machine obta...

A piston and a cylinder machine obtains a fluid system, which passes through a complete cycle of four processes. In the mean while a cycle the sum of all heat transfer is 150KJ and

Tom, ‘coefficient of insensitiveness’ of governors

‘coefficient of insensitiveness’ of governors

What is fictitious force??, A fictious force or pseudo force is an imaginar...

A fictious force or pseudo force is an imaginary force that acts on a body in non inertial frame. it is opposite in direction of accelaration of non inertial frame.

Determine and illustrate about the earth pressure at rest, Determine and il...

Determine and illustrate about the earth pressure at rest. EARTH PRESSURE AT REST You have seen that the active pressure is the minimum lateral pressure while the passive pr

Diesel cycle, The pressure and temperature of a diesel cycle at the start a...

The pressure and temperature of a diesel cycle at the start are 1 bar and 20C respectively and the compression ratio is 14. The pressure at the end of expansions 2.5 bar. Find perc

Applied load shall elongate the spring, Applied load shall elongate the spr...

Applied load shall elongate the spring: Design a close coiled helical spring which shall deflect 100 mm under a load of 600 N. The radius of the coil is 6 times the wire diame

Carburettor tuning of motorcycle, Carburettor Tuning :  It is very importa...

Carburettor Tuning :  It is very important that the carburettor is tuned properly to attain the best fuel efficiency and performance of the motorcycle. Since air screw is factory

Airport pavement, Airport Pavement: Airport pavements can be: (a) ...

Airport Pavement: Airport pavements can be: (a)        Flexible, and (b)       Rigid (cement concrete). Since cement concrete pavements have transverse and longitudi

__, what is magnetostriction?

what is magnetostriction?

Determine the axial extension along a load, Determine the axial extension a...

Determine the axial extension along a load: An open coiled helical spring is created having 10 turns of a mean radius of 60 mm. The wire diameter is 10 mm and coils make an an

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd