Original hodgkin-huxley model, Mechanical Engineering

Assignment Help:

1. Plot the functions x1 and x as functions of voltage

2. Assume that you hold the membrane potential V at -120 mV until the system reaches equilibrium (i.e. until dx=dt = 0, where x = (V;m; h; n; a; b;M;H)T ) and that at time t = 0 you suddenly change and hold the value of the membrane potential at a value Vo. Plot the currents IL, INa, IK, IA, ICaT as well as the total current as functions of time for a number of di erent values Vo of you choice in the range -75 to +40 mV.

3. Write an algorithm for numerically approximating the solution to the above model.

4. Using the algorithm you developed in Question 2, illustrate the presence of post-inhibitory rebound (PIR) in the above model.

5. Using the algorithm you developed in Question 2 and assuming that ICaT is completely blocked (i.e. GCaT = 0), construct the gain function of the above model.

6. How does the gain function you constructed in Question 5 di er from the gain function of the original Hodgkin-Huxley model?


Related Discussions:- Original hodgkin-huxley model

Baffles, Four diametrically opposed in vessels up to pilot scale. More appl...

Four diametrically opposed in vessels up to pilot scale. More applied in production vessels. Thickness typically 0.1 - 0.05 tank diameter. Baffle height is dependent on the gas

Boiler, parameters specified in a steam boiler

parameters specified in a steam boiler

Calculate change of entropy of universe, Calculate change of entropy of uni...

Calculate change of entropy of universe: 5Kg of ice at 10 0 C is kept in atmosphere that is at 30 0 C. Calculate change of entropy of universe when it melts and comes i

Mechanics materials , 1) Factor of Safety is calculated by using which of t...

1) Factor of Safety is calculated by using which of the following set of values? [Select the one best answer from the choices given below.] Answer a. Yield Stress and Allowable St

Newtons ring, a plano concave lens is used instead of plano convex lens in ...

a plano concave lens is used instead of plano convex lens in newtons ring

Calculate the maximum bending movement, A beam, 6 m long is simply supporte...

A beam, 6 m long is simply supported at the ends, and carries a uniformly distributed load of 15 KN/m and three loads of 10 KN, 20 KN and 30 KN acting respectively at the centre po

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd