Original hodgkin-huxley model, Mechanical Engineering

Assignment Help:

1. Plot the functions x1 and x as functions of voltage

2. Assume that you hold the membrane potential V at -120 mV until the system reaches equilibrium (i.e. until dx=dt = 0, where x = (V;m; h; n; a; b;M;H)T ) and that at time t = 0 you suddenly change and hold the value of the membrane potential at a value Vo. Plot the currents IL, INa, IK, IA, ICaT as well as the total current as functions of time for a number of di erent values Vo of you choice in the range -75 to +40 mV.

3. Write an algorithm for numerically approximating the solution to the above model.

4. Using the algorithm you developed in Question 2, illustrate the presence of post-inhibitory rebound (PIR) in the above model.

5. Using the algorithm you developed in Question 2 and assuming that ICaT is completely blocked (i.e. GCaT = 0), construct the gain function of the above model.

6. How does the gain function you constructed in Question 5 di er from the gain function of the original Hodgkin-Huxley model?


Related Discussions:- Original hodgkin-huxley model

Show continuity equation in cylindrical coordinates, Show continuity equati...

Show continuity equation in cylindrical coordinates. Also list the assumptions made. A fluid flow is given by V = xy 2 i - 2yz 2 j - (zy 2 - 2z 3 /3) k Determine acceleration

#totto cycleitle.., for an otto cycle, compression ratio=8.5:1,air inlet=15...

for an otto cycle, compression ratio=8.5:1,air inlet=15degree celsius and pressure=101.3kpa, maximum cycle temperature= 1800degree celsius, what is temperature after compression,te

Moment of inertia.., mathematical expression of moment of inertia

mathematical expression of moment of inertia

Evaluate the rankine efficiency, In a Rankine cycle, the steam at inlet to ...

In a Rankine cycle, the steam at inlet to turbine is saturated at a pressure of 35 bar and the exhaust pressure is 0.2 bar. Evaluate: (i) The pump work, (ii) The turb

Copper-lead alloys, Copper-Lead Alloys Copper-lead alloys, having a la...

Copper-Lead Alloys Copper-lead alloys, having a large percentage of lead have determined a considerable employ as bearing material lately. Straight, copper-lead alloys of such

Mechanism of laser welding, MECHANISM OF LASER WELDING   Laser weldi...

MECHANISM OF LASER WELDING   Laser welding of metals is performed with beams focused to irradiate levels in the range of 106 to 107 W / cm 2 . At such power densities, melti

Industrial jobs, i wanna know is production job is best or marketing after ...

i wanna know is production job is best or marketing after doing btech

Determine the work related area of cad, Work related area of CAD Work r...

Work related area of CAD Work related to the following areas has been addressed in this interface.  Investigation of CAD data structures and the presentation of 2-D and

Illustrate the spatial partitioning representation, Normal 0 fa...

Normal 0 false false false EN-IN X-NONE X-NONE MicrosoftInternetExplorer4

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd