Original hodgkin-huxley model, Mechanical Engineering

Assignment Help:

1. Plot the functions x1 and x as functions of voltage

2. Assume that you hold the membrane potential V at -120 mV until the system reaches equilibrium (i.e. until dx=dt = 0, where x = (V;m; h; n; a; b;M;H)T ) and that at time t = 0 you suddenly change and hold the value of the membrane potential at a value Vo. Plot the currents IL, INa, IK, IA, ICaT as well as the total current as functions of time for a number of di erent values Vo of you choice in the range -75 to +40 mV.

3. Write an algorithm for numerically approximating the solution to the above model.

4. Using the algorithm you developed in Question 2, illustrate the presence of post-inhibitory rebound (PIR) in the above model.

5. Using the algorithm you developed in Question 2 and assuming that ICaT is completely blocked (i.e. GCaT = 0), construct the gain function of the above model.

6. How does the gain function you constructed in Question 5 di er from the gain function of the original Hodgkin-Huxley model?


Related Discussions:- Original hodgkin-huxley model

Determine the stresses acting on the plan, Using Mohr's Circle Method deter...

Using Mohr's Circle Method determine the stresses acting on the plan as shown in figure. Also write the procedure.

Hydraulic jack, explain the operation manual of a hydraulic jack

explain the operation manual of a hydraulic jack

COMPRESSOR PROBLEM FROM CUSTOMER, OUR CUSTOMER HAD APROBLEM WITH OUR CUSTO...

OUR CUSTOMER HAD APROBLEM WITH OUR CUSTOMER ,AND ME AS AMECHANICLAL ENGINEER FOUND THE PROBLEM

Define what is nose radius, Define What is Nose Radius? The nose radius...

Define What is Nose Radius? The nose radius is provided to increase finish and strength of the cutting tip of the tool. Small radii will produce smooth finish and are used on t

Determine the deflection , Obtain the equations of the elastic curve and us...

Obtain the equations of the elastic curve and use them to determine the deflection and rotation at point B in terms of E, I, F and L.

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd