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Most proteins made by ribosomes on the RER (rough endoplasmic reticulum) are glycoproteins, which is they hold short chains of carbohydrates (oligosaccharides) covalently related to them during passage by the Golgi and RER complex. Two major types of oligosaccharide linkage exist:
? O-linked oligosaccharides are commonly attached to the protein through O-glycosidic bonds to OH groups of Thr or Ser side chains. The residues which are changed are frequently in a region of the polypeptide chain which is rich in Thr and Ser residues. In plant glycoproteins, the OH sets of hydroxyproline (Hyp) residues can be glycosylated, by the hydroxylysine (Hyl) reduce in the mammalian protein collagen can be O-glycosylated.
? N-linked oligosaccharides are related to the protein via N-glycosidic will bonds to the NH2 where the Asn occurs in the sequence Asn-X-Ser (or Thr) where X is many amino acids except Pro. If the Asn is N-glycosylated the Thr or Ser residue in this motif is not O-glycosylated.
Echocardiographic evaluation should be performed in all patients with clinically suspected IE, including those with negative blood cultures. Not only is TEE the preferred approach
Explain Fosamprenavir calcium It is a prodrug of amprenavir, was recently approved by the FDA for use in HAART. In patients who have not lastly been treated with a protease inh
Which is the part of the human visual system where the receptors that sense light, i.e., the photoreceptor cells, are located? How do those cells work? The photoreceptor cells
CELL MEMBRANE It is biological, thin, elastic, flexible & selective permeable membrane. Term "Cell membrane" was coined by Negeli & Crammer 1855. Term " Plasma membr
Q. Counselling Elderly Diabetics? The rising trend of diabetes in the elderly population is a challenge for health care providers. The problems which make the diabetes treatmen
Lung Biopsy: As with pleural biopsy, lung biopsy may be done by surgical exposure of the lung (open lung biopsy) with or without endoscopy using a needle designed to remove a
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How to load glycogen? Over the past fifty years, the biggest breakthrough was the discovery of how to load glycogen and sophistication in the methods of glycogen loading. Nitro
Production of Disease-free Plants Under normal conditions plants are infected by a wide range of pathogens such as bacteria, fungi, viruses, viroids, and insects like nematode
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