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Most proteins made by ribosomes on the RER (rough endoplasmic reticulum) are glycoproteins, which is they hold short chains of carbohydrates (oligosaccharides) covalently related to them during passage by the Golgi and RER complex. Two major types of oligosaccharide linkage exist:
? O-linked oligosaccharides are commonly attached to the protein through O-glycosidic bonds to OH groups of Thr or Ser side chains. The residues which are changed are frequently in a region of the polypeptide chain which is rich in Thr and Ser residues. In plant glycoproteins, the OH sets of hydroxyproline (Hyp) residues can be glycosylated, by the hydroxylysine (Hyl) reduce in the mammalian protein collagen can be O-glycosylated.
? N-linked oligosaccharides are related to the protein via N-glycosidic will bonds to the NH2 where the Asn occurs in the sequence Asn-X-Ser (or Thr) where X is many amino acids except Pro. If the Asn is N-glycosylated the Thr or Ser residue in this motif is not O-glycosylated.
Explain the Sampling and Analysis of Microbial Load? A food or equipment can be free of visible dirt and still be carrying microorganisms or chemicals that can cause food borne
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State two characteristics of humans which distinguish them from other primates. Two features which differentiate humans from other primates are their upright posture and their
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If an enzyme-controlled reaction normally takes place at 10ºC, in general terms how will the reaction be affected by (a) a fall in temperature to 2°C , (b) a rise in temperature t
Find the equilibrium molality of solute species? Consider a hypothetical system in which two aqueous solutions are separated by a semipermeable membrane. Solution α is prepared
The reported occurrence of ICMAs is 1.2 per cent to 5 per cent of cases. Streptococci and S.aureus account for 50 per cent and 10 per cent of cases, respectively, and are seen with
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