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Most proteins made by ribosomes on the RER (rough endoplasmic reticulum) are glycoproteins, which is they hold short chains of carbohydrates (oligosaccharides) covalently related to them during passage by the Golgi and RER complex. Two major types of oligosaccharide linkage exist:
? O-linked oligosaccharides are commonly attached to the protein through O-glycosidic bonds to OH groups of Thr or Ser side chains. The residues which are changed are frequently in a region of the polypeptide chain which is rich in Thr and Ser residues. In plant glycoproteins, the OH sets of hydroxyproline (Hyp) residues can be glycosylated, by the hydroxylysine (Hyl) reduce in the mammalian protein collagen can be O-glycosylated.
? N-linked oligosaccharides are related to the protein via N-glycosidic will bonds to the NH2 where the Asn occurs in the sequence Asn-X-Ser (or Thr) where X is many amino acids except Pro. If the Asn is N-glycosylated the Thr or Ser residue in this motif is not O-glycosylated.
GRADIEN T THEORY - It was given by T. Boveri & was supported by M.C. Child. Child called it as metabolic axial gradient theory. According to it, the egg has distinct ani
Aspect of Tolerance and Dependence: Drug-abusers are said to be psychologically dependent upon certain drugs. Drugs also induce clear physical dependence in the chronic users.
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The Polymerase Chain Reaction Kary Mullis established the technique of the polymerase chain reaction (PCR) in the year of 1983. He won a Nobel Prize for the procedure in the ye
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Define Inadequate Dietary Intake - cause of anaemia is dietary? The commonest cause of anaemia is dietary inadequacy of iron. The dietary intakes arc usually half of the recomm
Figure shows part of a DNA molecule (a) (i) What do the dotted lines in Figure represent? (ii) Name J to M. J.............................. K..............................
What is Coevolution ? There is considerable evidence that supports an interesting theory that two individual species can affect each others evolution in reciprocal fashion. In
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