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They result from septic embolization of vegetations to the arterial vasa vasorum or the intraluminal space, with subsequent spread of infection through the intima and outward through the vessel wall. Arterial branching points favour the impaction of emboli and are the most common sites of MA development. MAs due to IE occur most frequently in the intracranial arteries, followed by visceral arteries and arteries of the lower and upper extremities.
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