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Multi-hit model is the model for a toxic response which results from the random occurrence of one or the more fundamental biological events. A response is supposed to be induced once the target tissue has been 'hit' by the number, k, of biologically effective units of dose within a particular time period. Assuming that the number of hits during this period follows a Poisson procedure, the probability of a response is given by
Law of likelihood : Within framework of the statistical model, a particular set of data supports one statistical hypothesis or assumption better than another if the likelihood of t
Geographical analysis machine is the procedure designed to detect the clusters of rare diseases in a particular area. Circles of fixed radii are created at each point of the squar
Range is the difference between the largest and smallest observations in the data set. Commonly used as an easy-to-calculate measure of the dispersion in the set of observations b
Least significant difference test is an approach to comparing a set of means which controls the family wise error rate at some specific level, let's assume it to be α. The hypothe
R-squared is regarded as the coefficient of determination and is used to give the proportion of the fluctuation of the variance of one variable to another variable. R-squared also
Computer-intensive methods : The statistical methods which require almost identical computations on the data repeated number of times. The term computer intensive is, certainly, a
Observational study is the study in which the objective is to discover cause-and-effect relationships but in which it is not feasible to use the controlled experimentation, in th
The Null Hypothesis - H0: Model does not fit the data i.e. all slopes are equal to zero β 1 =β 2 =...=β k = 0 The Alternative Hypothesis - H1: Model does fit the data i.e. at
Non central distributions is the series of probability distributions each of which is the adaptation of one of the standard sampling distributions like the chi-squared distributio
Common cause failures (CCF): Simultaneous failures of the number of components due to a same reason. A reason can be external to the components, or it can be the single failure wh
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