Molecular response to thyroid hormones, Operation Management

Assignment Help:

Molecular Response to Thyroid Hormones during Metamorphosis

Thyroid hormones can cause obtainable tissues to break down or can remold the tissues to their adult function. The liver cells of the tadpole for instance are not destroyed and replaced during metamorphosis. In place of their structure is remodeled. This change is accompanied by dramatic raise in ribosomal and messenger RNA synthesis. The rate of protein synthesis also increases nearly 100 folds in four hours of thyroid hormone stimulation. Many of the new mRNAs are those that code for new functions of the liver. The main increase in protein synthesis appears to come from the transcription of new m-RNAs.

Carbamoylphosphate synthase (a urea cycle enzyme) is synthesized after the burst of RNA synthesis. Experiments have illustrated three types of molecular response to thyroid hormone. One set of genes increases its low level of transcription in reply to either natural or thyroxine induced metamorphosis. Another set of genes decreases its rate of transcription, whereas a third set of genes remains unaffected by thyroid hormones. Mori and Coworkers (1979) have illustrated that much of the increase in Carbamoylphosphate synthase can be attributed to increased transcription from the gene. So metamorphosis appears to some extent to be controlled at the transcriptional level. Other evidences also indicate the capability of thyroid glands to regulate gene activity at the level of transcription. This does not mean that transcription is the only level of gene regulation, operative during metamorphosis, but it is obviously an important one.


Related Discussions:- Molecular response to thyroid hormones

Explain does either couple pay a marriage tax, Jabus and Kelsey are a marri...

Jabus and Kelsey are a married couple with no children. Each earns $120,000 per year, and their combined household adjusted gross income is $240,000. Anthony and Caitlin, who are m

Interdependent sub systems - operations function, Interdependent sub-system...

Interdependent sub-systems A striking feature of complex, open systems is that each comprises a set of highly interdependent sub-systems. For instance, the human body consist

Factors determining production control, Factors Determining Production Cont...

Factors Determining Production Control 1. Nature of Production: In job oriented manufacturing products and operations designed for some particular order which may or may not b

Line balancing, What do you understand by “line balancing”? What happens if...

What do you understand by “line balancing”? What happens if balance doesn’t exist

Define challenges has the european union consortium faces, Describe what ch...

Describe what challenges has the European Union Consortium faced in the last 2-3 years

Explain stakeholders of a company are shareholders, Stakeholders of a compa...

Stakeholders of a company are shareholders, the community, customers, employees, and all of the other parties that have an interest in seeing that the company succeeds. True False

Explain repetition of new product, You are a consultant called in to estima...

You are a consultant called in to estimate the costs after the employees learn how to do a job more efficiently by repetition of new product. You find a company can produce a produ

States gross national product, States Gross National Product (GNP) Gr...

States Gross National Product (GNP) Gross Domestic Product (GDP) adjusted for foreign earnings.

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd