Molecular response to thyroid hormones, Operation Management

Assignment Help:

Molecular Response to Thyroid Hormones during Metamorphosis

Thyroid hormones can cause obtainable tissues to break down or can remold the tissues to their adult function. The liver cells of the tadpole for instance are not destroyed and replaced during metamorphosis. In place of their structure is remodeled. This change is accompanied by dramatic raise in ribosomal and messenger RNA synthesis. The rate of protein synthesis also increases nearly 100 folds in four hours of thyroid hormone stimulation. Many of the new mRNAs are those that code for new functions of the liver. The main increase in protein synthesis appears to come from the transcription of new m-RNAs.

Carbamoylphosphate synthase (a urea cycle enzyme) is synthesized after the burst of RNA synthesis. Experiments have illustrated three types of molecular response to thyroid hormone. One set of genes increases its low level of transcription in reply to either natural or thyroxine induced metamorphosis. Another set of genes decreases its rate of transcription, whereas a third set of genes remains unaffected by thyroid hormones. Mori and Coworkers (1979) have illustrated that much of the increase in Carbamoylphosphate synthase can be attributed to increased transcription from the gene. So metamorphosis appears to some extent to be controlled at the transcriptional level. Other evidences also indicate the capability of thyroid glands to regulate gene activity at the level of transcription. This does not mean that transcription is the only level of gene regulation, operative during metamorphosis, but it is obviously an important one.


Related Discussions:- Molecular response to thyroid hormones

Explain the network is overloaded, Information asymmetry exists when - T...

Information asymmetry exists when - The network is overloaded - Sellers and buyers have the same information - One party in a transaction had more important information th

Explain make-or-buy in decision, Consider the make-or- buy in decision. Giv...

Consider the make-or- buy in decision. Give three examples of situations in which a business should make, rather than buy. Give three examples of situations in which a business sho

How many earrings needed, Raj has a jewel chest containing Rings, Pins and ...

Raj has a jewel chest containing Rings, Pins and Ear-rings. The chest contains 26 pieces. Raj has 2 1/2 times as many rings as pins, and the number of pairs of earrings is 4 less t

Explain need step by step solutions to case study, Need step by step soluti...

Need step by step solutions to case study 2-1 (auto-assembly)

The graph that depicts the utility value versus monetary, The graph that pl...

The graph that plots the utility value versus monetary value is called a

How to perform a decision tree analysis for problem, Mountain States Electr...

Mountain States Electric Service is an electrical utility company serving several states in the Rocky Mountains region. It is considering replacing some of its equipment at a gener

Explain some inherent challenges in using decision trees, What are some inh...

What are some inherent challenges in using decision trees effectively in today's organizations? How can these challenges be overcome?

Product layout., define the following key terms in product layout; product...

define the following key terms in product layout; product interval time, product duration, assembly line balancing

The chair business uses price as major competitive factors, Management beli...

Management believes they can increase the price per chair by 10 percent in this new situation and improve profits by 10 percent. However, the sales department cautions that the pri

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd