Progress on these biological issues needs both that more mathematics and statistics be brought to bear on them and that new mathematical and statistical tools be prepared. All the biological questions share some common themes: i) interactions of process at different characteristic spatial and temporal scales; ii) stochastic, or random, forces that affect biological systems; iii) complex, interacting process that produce data which are hard to visualize, manipulate, and analyze; and iv) natural variability and observation imprecision that introduces unavoidable uncertainty in our ability to characterize biological pehnomena. Addressing these common themes will need all branches of mathematics and statistics, from intensive computer simulations that attempt to mimic biological systems to elegant paper-and-pencil theorems that give conceptual understanding and generality to biological problems.