Insulators - transgenic animals, Biology

Assignment Help:

Insulators

Numerous experiments showed that a transgene is generally poorly expressed when it contains a cDNA rather than the corresponding genomic DNA; when it is integrated as multiple copies; when it contains non mammalian DNA sequences, namely CpG- rich sequences; and when it is integrated in a silent region of chromatin. The last phenomenon is known as position effect.Vector constructions may be performed taking these observations into account. It is now acknowledged that groups of genes, acting or not acting in a coordinated manner, are bordered by DNA sequences that insulate them from the rest of the chromosome. These sequences have been named insulators or LCRs (locus control regions). Insulators are composed of multiple elements. The inclusion of insulators in gene constructs greatly enhances the transgene expression.


Related Discussions:- Insulators - transgenic animals

What are biotic factors, What are biotic factors? Biotic factors are li...

What are biotic factors? Biotic factors are living beings (plants, microorganisms and animals) that are part of a given environment.

Describe about the primary prevention - food allergy, Describe about the Pr...

Describe about the Primary Prevention - Food Allergy? Let us further, dwell on measures we could adopt in primary, secondary and tertiary prevention. Current research in primar

What is cyanobacteria or blue-green bacteria, What is Cyanobacteria or Blue...

What is Cyanobacteria or Blue-green bacteria? Blue-green bacteria, or cyanobacteria, used to be classified as blue-green algae within the Plant Kingdom, primarily because they

Illustrate the aqueous phase in sol processing, Illustrate the aqueous phas...

Illustrate the aqueous phase in sol processing In a sol possessing a continuous aqueous phase, the colloidal particles have an electrically charged surface.  The ionized groups

Cancer lung, Cancer Lung Incidence of cancer lung is more in persons ...

Cancer Lung Incidence of cancer lung is more in persons who smoke. Environmental and industrial pollution is also a risk factor in the increase in incidence. Clinic

What a diploid cell contains, A diploid cell contains: A.one half of a comp...

A diploid cell contains: A.one half of a complete set of chromosomes B.several complete sets of chromosomes C.the correct number of chromosomes D.two complete sets of chromosomes E

What is the function of vitamin e, Q. What is the function of vitamin E? In...

Q. What is the function of vitamin E? In which foods can it be found? Vitamin E is also known as tocopherol is a fat-soluble vitamin that participates as coenzyme in the respir

Regulation of heart, Regulation of Heart The number of electrical imp...

Regulation of Heart The number of electrical impulses initiated by the SA node is primarily the result of its innervation by fibers from both sympathetic and parasympath

Define st elevation in avr, Q. Define ST Elevation in aVR? Lead aVR oft...

Q. Define ST Elevation in aVR? Lead aVR often develops ST elevation as a reciprocal of ST depression in lead V2 to V6 or leads 2 and 3. It may occasionally show ST elevation in

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd