A) Definitive Infective Endocarditis

1) Pathological Criteria

• Micro organism: demonstrated by culture or histology in a vegetation; or in a vegetation that has embolized, or in an intra cardiac abcess, or
• Pathological lesions: vegetation or intracardiac abscess present, confirmed by histology showing active endocarditis.

2) Clinical Criteria, using specific definitions listed below:

• Two major criteria, or
• One major and three minor criteria, or
• Five minor criteria.

B) Possible Infective Endocarditis

• One major +1 minor or 3 minor.

C) Rejected

• Firm alternative diagnosis for manifestations of endocarditis, or
• Sustained resolution of manifestations of endocarditis, with antibiotic therapy for 4 days or less, or
• No pathological evidence of infective endocarditis at surgery or autopsy, after antibiotic therapy for 4 days or less.