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Q. Illustrate Hypertrophic cardiomyopathy?
It is a genetic disorder due to mutations in the gene that encodes for β-Cardiac myosin heavy chain (Localised to chromosome 14). It is characterized by inappropriate myocardial hypertrophy in absence of hypertension or aortic stenosis. There is myocardial disarray and interstitial fibrosis. It has asymmetric septal hypertrophy, left ventricular outflow obstruction due to systolic anterior motion of mitral valve, LV diastolic dysfunction, myocardial ischaemia and arrhythmias. LV outflow obstruction occurs only in about ¼th. The prevalence of HCM is about 0.2 per cent.
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