How the dna nanoarchitecturing works, Biology

Assignment Help:

Q. How the DNA nanoarchitecturing works?

DNA Nano architectures constructs that can be self-assembled from branched DNA molecules. Their components can be simple branched species or more complex structural motifs. Simple branched DNA junctions have been produced that comprise 3-12 double helices flanking a branch point. Species can be assembled or/and ligated into DNA stick polyhedra, where edges are DNA double helices and vertices correspond to branch points of junctions. The first such molecule was a DNA molecule with the connectivity of a cube. Otherpolyhedra produced to date contain a tetrahedron, an octahedron as well as a truncated octahedron. Branched junctions are somewhat floppy, so only branching and linking topologies of polyhedral are well defined unless all faces are triangles. Other individual objects which have been built are topological targets, like knots and Borromean rings. DNA is an ideal species to use as a topological building block since a half-turn of DNA is equivalent to a node, which is fundamental topological feature of a catenane or aknot. DNA doublecrossover (DX) molecule is another key element in DNA nanoarchitectures. This motif comprise two helices joined twice by strands that connect them, leading to parallel helix axes; connection points are separated typically by Two-dimensional DNA lattice. One and two double helical turns. Each of connection points is a four-arm junction, so motif can be explained as two four-arm junctions joined twice to eachother at adjacent arms. These are robust motifs, generally three to six double helical turns in length and their structures can be reliably predicted. This system can be extended, leading to molecules containing three or more helices joined laterally. Even though most often built to be roughly planar motifs, angles canbe varied between pairs of helices, using helicity of DNA, for example a six-helix cyclic motif has been reported that approximates a hexagonal tube (→DNA nanotubes). DX molecules and their relatives can be used as tiles to produce two-dimensional crystalline arrangements by self-assembly (→DNA self-assembly). An extra motif can be included in these tiles, visible when crystal is viewed in an atomic force microscope. Accompanying picture demonstrates how arrangements of two 16 × 4 nm tiles produce 32-nm stripes (top) or four tiles produce 64-nm stripes (bottom). Along with periodic arrangements, aperiodic patterns can also be generated algorithmically. Single-stranded bacteriophages have been used to produce greatly extended versions of parallel DNA motif, capable of yielding highly elaborate patterns, in a method known as DNA origami. This is done by using bacteriophage genome (several thousand nucleotides)as a template to which a large number of "staple strands" are added to fold genome into a specific shape, including holes in the middle; addition of strands containing extra domains enable the generation of further features. Smiley faces and a map of western hemisphere are instances of patterns generated by this method.


Related Discussions:- How the dna nanoarchitecturing works

Describe about diagnostic approach congenital heart disease, Describe about...

Describe about diagnostic approach for congenital heart disease ? In this section we propose to outline the principles of a diagnostic approach that is applicable to newborns,

Structure of the human vision apparatus, Q. What are the structures that co...

Q. What are the structures that compose the human vision apparatus? The organs of the human visual apparatus are the eyes the optical nerves and the visual areas of the brain l

What is rate of photosynthesis in c3 plants, What would happen to the rate ...

What would happen to the rate of photosynthesis in C3 plants if the CO2 concentration level almost doubles from its present level in the atmosphere?

Small for gestational age & intrauterine growth retardation, Define Small f...

Define Small for Gestational Age and Intrauterine Growth Retardation? Small for Gestational Age (SGA) is defined as infants affected by intrauterine growth restriction (IUGR).

Nursing assessment - anomalies of stomach and oesophagus, Nursing Assessmen...

Nursing Assessment  These children present with excessive salivation and droofing of saliva from the mouth, coughing, gagging, even choking and cyanosis at the lime of first f

Phimosis, Phimosis Phimosis may be congenital or acquired. The foreski...

Phimosis Phimosis may be congenital or acquired. The foreskin in young infants cannot be retracted, because at that gge it is adherent to the underlying glans. Wlen an attemp

Signify the term - analogy, Signify the term - Analogy, Analogous? Refe...

Signify the term - Analogy, Analogous? Refers to structures that do not have the same evolutionary origin but have the same functions. The wings of a bat and insect are analogo

How phytohormones help development of parthenocarpic fruits, How phytohormo...

How phytohormones help the development of parthenocarpic fruits? The Parthenocarpic fruits are those produced with no fecundation. Several plants naturally make parthenocarpic

Vaso-constriction, what is a vaso-constriction? what are the effects of vas...

what is a vaso-constriction? what are the effects of vaso-constriction in the skin?

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd