How the dna nanoarchitecturing works, Biology

Assignment Help:

Q. How the DNA nanoarchitecturing works?

DNA Nano architectures constructs that can be self-assembled from branched DNA molecules. Their components can be simple branched species or more complex structural motifs. Simple branched DNA junctions have been produced that comprise 3-12 double helices flanking a branch point. Species can be assembled or/and ligated into DNA stick polyhedra, where edges are DNA double helices and vertices correspond to branch points of junctions. The first such molecule was a DNA molecule with the connectivity of a cube. Otherpolyhedra produced to date contain a tetrahedron, an octahedron as well as a truncated octahedron. Branched junctions are somewhat floppy, so only branching and linking topologies of polyhedral are well defined unless all faces are triangles. Other individual objects which have been built are topological targets, like knots and Borromean rings. DNA is an ideal species to use as a topological building block since a half-turn of DNA is equivalent to a node, which is fundamental topological feature of a catenane or aknot. DNA doublecrossover (DX) molecule is another key element in DNA nanoarchitectures. This motif comprise two helices joined twice by strands that connect them, leading to parallel helix axes; connection points are separated typically by Two-dimensional DNA lattice. One and two double helical turns. Each of connection points is a four-arm junction, so motif can be explained as two four-arm junctions joined twice to eachother at adjacent arms. These are robust motifs, generally three to six double helical turns in length and their structures can be reliably predicted. This system can be extended, leading to molecules containing three or more helices joined laterally. Even though most often built to be roughly planar motifs, angles canbe varied between pairs of helices, using helicity of DNA, for example a six-helix cyclic motif has been reported that approximates a hexagonal tube (→DNA nanotubes). DX molecules and their relatives can be used as tiles to produce two-dimensional crystalline arrangements by self-assembly (→DNA self-assembly). An extra motif can be included in these tiles, visible when crystal is viewed in an atomic force microscope. Accompanying picture demonstrates how arrangements of two 16 × 4 nm tiles produce 32-nm stripes (top) or four tiles produce 64-nm stripes (bottom). Along with periodic arrangements, aperiodic patterns can also be generated algorithmically. Single-stranded bacteriophages have been used to produce greatly extended versions of parallel DNA motif, capable of yielding highly elaborate patterns, in a method known as DNA origami. This is done by using bacteriophage genome (several thousand nucleotides)as a template to which a large number of "staple strands" are added to fold genome into a specific shape, including holes in the middle; addition of strands containing extra domains enable the generation of further features. Smiley faces and a map of western hemisphere are instances of patterns generated by this method.


Related Discussions:- How the dna nanoarchitecturing works

State the principle of adaptation, State the Principle of Adaptation Th...

State the Principle of Adaptation The first principle is that the central goal of assessment is to promote the adaptation of the child, rather than simply to document the prese

Name mimicry by which insect mimics insec for protection, From the followin...

From the following, name the type of mimicry by which a palatable, acceptable insect mimics an unfavorable, noxious insec for protection. a) Batesian mimicry (pron: BATE-see-an

Determine possible polypeptides, a) The image above is part of a DNA sequen...

a) The image above is part of a DNA sequencing gel. Assuming this is the DNA coding strand and you are reading 5' -> 3' what are ALL the possible polypeptides this sequence cou

Define the term- organismal complexity, Which of the following statements l...

Which of the following statements least accurately explains our knowledge of how gene number relates to "organismal complexity"? A. Based on known gene numbers there appears to

Chromophore - development of plant, Chromophore - Development of plant ...

Chromophore - Development of plant The chromophore is a tetrapyrrole molecule like chlorophyll, but unlike chlorophyll it is an open tetrapyrrole and contains no metal ion. It

Effects on weather - air pollutants, Effects on Weather - Air pollutants ...

Effects on Weather - Air pollutants Dust, smoke and other suspended particulate matter reduce visibility. Fly-ash also affects visibility by intercepting and scattering solar

Nervous system control of blood pressure, Q. Nervous System control of bloo...

Q. Nervous System control of blood pressure? Most nervous controls are achieved via involuntary reflex arcs involving pressoreceptors, the vasomotor centers of the medulla, and

Staging of heart failure, In this unit you have learnt that heart failure i...

In this unit you have learnt that heart failure is one of the most common conditions seen and results in a high mortality. It can result from failure of the heart muscle as with co

Introduction to transgenic animals, Transgenic Animal Over the centurie...

Transgenic Animal Over the centuries, animals with new combinations of genes have been produced using conventional breeding methods by means of careful selection of particular

Molecular diagnostic, molecular test protocol for infectious disease and fu...

molecular test protocol for infectious disease and full test procedure and scientific flyer

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd