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How does the immune process that causes the hemolytic disease of the newborn take place?
In a hemolytic disease of the newborn the mother has Rh- blood and this mother when generating her first Rh+ child makes contact, possibly during delivery, with Rh+ red blood cells of the child and her immune system triggers the primary immune response against the Rh factor. In a next gestation in which the fetus is Rh+ the mother will already have much more anti-Rh antibodies in her circulation; these antibodies cross the placental barrier and gain the fetal circulation causing fetal hemolysis (destruction of the red blood cells of the fetus).
The immune response involves the activities of proteins, cells, and the lymphatic system.
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