Genetic defect in pyruvate dehydrogenase, Biology

Assignment Help:

Genetic Defect in Pyruvate Dehydrogenase

A defed in any of  the protein subunits of PDH can result in decrease or complete loss of  activity. Severe cases are usually fatal. Symptoms  of deficiency include:

a)  Lactic acidosis, and

b)  Neurologic disorders.  .

Chronic alcoholics suffer  fiom  the deficiency of,thiamin,  which results  in the  accumulation of pyruvic acid. Excess pyruvate is also reduced to lactate leading to potentially fatal pyruvic and lactic acidosis.

 


Related Discussions:- Genetic defect in pyruvate dehydrogenase

What does boiling do to an enzyme, What does boiling do to an enzyme? Enz...

What does boiling do to an enzyme? Enzymes are denatured (their shape is changed so it doesn't work) when boiled.

Explain about the dna viruses - carcinogenic, Explain about the DNA viruses...

Explain about the DNA viruses - Carcinogenic? The three DNA viruses found to cause human cancers are EBV, HBV and HPV. What are these? Let us find out. Epstein-Barr viru

How can asexual reproduction in planarias be described, How can asexual rep...

How can asexual reproduction in planarias be described? Planarias can separate themselves asexually by transversal bipartition because of the great regeneration capability of t

Animal nutrition - zoology, Anima l Nutrition Nutrition is the procu...

Anima l Nutrition Nutrition is the procurement of substances necessary for growth, maintenance and activities of a living body. The substances used for nutrition are called

How hiv infection works, How do antibody-based tests detect how HIV infecti...

How do antibody-based tests detect how HIV infection works? After the infection by the HIV the immune system starts the production of antibodies (primary immune response) again

Stress testing after myocardial infraction, Q. Stress Testing after Myocard...

Q. Stress Testing after Myocardial Infraction? Many post infarction deaths are sudden and occur with in the first 6 months after infarction. Exercise testing from 10 days to we

What are coacervates, What are coacervates? Coarcervates are small stru...

What are coacervates? Coarcervates are small structures made of the aggregation of organic molecules under water solution. By electrical attraction the molecules join into bigg

Tingling or numbness in hands - symptoms of diabetes, Tingling or numbness...

Tingling or numbness is seen in cases of neuropathy. It occurs gradually over time. As high sugar (glucose) in the blood damages the nervous system, particularly in the extremities

Zone of polarizing activity (zpa), Zone of Polarizing Activity (ZPA) T...

Zone of Polarizing Activity (ZPA) The A-P axis is the 1 st axis to be fixed in the presumptive limb mesoderm at a very early stage. On the basis of results of a series of cur

Define functions of manganese, Define Functions of Manganese? Like othe...

Define Functions of Manganese? Like other micro minerals, Mn also functions in mammalian enzyme systems. It can function both as an integral part of metalloenzymes and as an en

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd