Genetic defect in pyruvate dehydrogenase, Biology

Assignment Help:

Genetic Defect in Pyruvate Dehydrogenase

A defed in any of  the protein subunits of PDH can result in decrease or complete loss of  activity. Severe cases are usually fatal. Symptoms  of deficiency include:

a)  Lactic acidosis, and

b)  Neurologic disorders.  .

Chronic alcoholics suffer  fiom  the deficiency of,thiamin,  which results  in the  accumulation of pyruvic acid. Excess pyruvate is also reduced to lactate leading to potentially fatal pyruvic and lactic acidosis.

 


Related Discussions:- Genetic defect in pyruvate dehydrogenase

What is the endosymbiotic hypothesis, Q. What is the endosymbiotic hypothes...

Q. What is the endosymbiotic hypothesis about the origin of mitochondria? And what are the molecular facts that support the hypothesis? And To which other cellular organelles can t

Summary of accident causation, Summary of Accident Causation In the li...

Summary of Accident Causation In the light of above theories it is concluded that the decision of workers to work safe is largely influenced by external factors such as meetin

Zoonoses disease-pseudorabies, Pseudorabies Pseudorabies is a viral di...

Pseudorabies Pseudorabies is a viral disease caused by pseudorabies virus (PRV) that is classified under family Herpesviridae. This disease is also known as “Aujeszky’s diseas

Explain what is pulse, Explain what is pulse ? Examination of periphera...

Explain what is pulse ? Examination of peripheral pulses as a very important step in cardiovascular examination. A normal pulse has upstroke (anacrotic limb) followed by a down

List the different systems of the body, List the different systems of the b...

List the different systems of the body a) Nervous System b) Respiratory System c) Cardiovascular System d) Neurological and Sensory System e) Gastrointestinal Syste

What is inflammation, What is inflammation? Inflammation is the initial...

What is inflammation? Inflammation is the initial response of the unspecific defense system versus aggressions against the body (the aggressions might be caused by infectious p

How two organisms are interdependent, Give an example of how two organisms ...

Give an example of how two organisms are interdependent. Animals generate carbon dioxide and water, which is required by plants. Accept all reasonable answers.

Evaluate the claim of sodium-dependent vitamin C transporter, Problem-solvi...

Problem-solving essay. Maximum 800 words. Deadline 12th of March. Show me you understand what this essay requires

Cation and anion, what is cation and anion? list of cation and anion and it...

what is cation and anion? list of cation and anion and its biological function?

Heat production, Heat Production In the Homeotherms heat production m...

Heat Production In the Homeotherms heat production must be elevated if the ambient temperature falls below the critical temperature. Although all metabolic processes result i

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd