Genetic defect in pyruvate dehydrogenase, Biology

Assignment Help:

Genetic Defect in Pyruvate Dehydrogenase

A defed in any of  the protein subunits of PDH can result in decrease or complete loss of  activity. Severe cases are usually fatal. Symptoms  of deficiency include:

a)  Lactic acidosis, and

b)  Neurologic disorders.  .

Chronic alcoholics suffer  fiom  the deficiency of,thiamin,  which results  in the  accumulation of pyruvic acid. Excess pyruvate is also reduced to lactate leading to potentially fatal pyruvic and lactic acidosis.

 


Related Discussions:- Genetic defect in pyruvate dehydrogenase

Explain brownian movement, Explain brownian movement When you view a so...

Explain brownian movement When you view a sol through an ultra microscope, you will observe that colloidal particles appear to be in a state of rapid and irregular motion calle

What is cold-shortening, What is cold-shortening It is important to poi...

What is cold-shortening It is important to point out that over-effective chilling of hot carcasses can lead to toughness. If the temperature of the meat (muscles) can be reduce

How to use a key, Q. How to Use a Key? The use of a key is analogous to...

Q. How to Use a Key? The use of a key is analogous to travelling a high way, that forks repeatedly, each fork having roadside directions. If a traveller follows the proper dire

Define briefly about vitamin B1, Vitamin B 1 (Thiamine hydrochloride) ...

Vitamin B 1 (Thiamine hydrochloride) a) Thiamine hydrochloride is a white, crystalline powder, slightly hygroscopic, of an odour resembling yeast and of bitter to taste. b)

Define different uses of additives in food, Normal 0 false fa...

Normal 0 false false false EN-US X-NONE X-NONE MicrosoftInternetExplorer4

Inheritence, What is inheritence and what is the relation between mendel an...

What is inheritence and what is the relation between mendel and darwin?

International codes used for system of binomial nomenclature, Q. Internatio...

Q. International Codes used for system of binomial nomenclature? In 1753 Linnaeus suggested a system of binomial nomenclature where each individual is denoted by two epithets,

Explain isomer, Isomer : Existence of different  compounds having  same ...

Isomer : Existence of different  compounds having  same  molecular form but different structural forms.

Determine the tenant of the cell theory, Determine the tenant of the Cell T...

Determine the tenant of the Cell Theory Which of the following is not a tenant of the Cell Theory as postulated by Mathias Schleiden and Theodor Schwann? A. All organisms a

Interaction of insect hormones, Interaction of insect hormones in the proce...

Interaction of insect hormones in the process of metamorphosis The organs and the hormones usually included in metamorphosis of insects. This is since despite the fact that t

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd