Genetic defect in pyruvate dehydrogenase, Biology

Assignment Help:

Genetic Defect in Pyruvate Dehydrogenase

A defed in any of  the protein subunits of PDH can result in decrease or complete loss of  activity. Severe cases are usually fatal. Symptoms  of deficiency include:

a)  Lactic acidosis, and

b)  Neurologic disorders.  .

Chronic alcoholics suffer  fiom  the deficiency of,thiamin,  which results  in the  accumulation of pyruvic acid. Excess pyruvate is also reduced to lactate leading to potentially fatal pyruvic and lactic acidosis.

 


Related Discussions:- Genetic defect in pyruvate dehydrogenase

Measurement and evaluation of food texture, Q. Measurement and Evaluation o...

Q. Measurement and Evaluation of Food Texture? Kinesthetic characteristics deal with the sense of feel, just like the characteristics of appearance deal with the sense of sight

Define altered glucose metabolism - nutrition during stress, Define Altered...

Define Altered Glucose Metabolism - Nutrition during Stress? Blood glucose levels are generally elevated in the infected patient but plasma insulin levels are normal or even hi

Why that property of water is important to life, Choose one property of wat...

Choose one property of water and explain why that property is important to life.

Minimal distance between the implants or an implant, What should be the min...

What should be the minimal distance between the implants or an implant and a natural tooth. The minimal distance between the implant and the adjacent tooth should be 1.5 -2 mm

Explain the meaning of protein deficiency, Explain the Protein Deficiency? ...

Explain the Protein Deficiency? One of the most common nutritional disorders in the world today is the deficiency of protein. Both adults and children are affected, as the popu

What phenotypic ratios of the diploid, A wild-type strain of haploid yeast ...

A wild-type strain of haploid yeast is crossed to a mutant haploid strain to make a diploid. What phenotypic ratios will be observed in the haploid progeny of the diploid?

Chromophore - development of plant, Chromophore - Development of plant ...

Chromophore - Development of plant The chromophore is a tetrapyrrole molecule like chlorophyll, but unlike chlorophyll it is an open tetrapyrrole and contains no metal ion. It

Molecular mechanism of hormone action, MOLECULAR MECHANISM OF HORMONE ACTIO...

MOLECULAR MECHANISM OF HORMONE ACTION - Once a hormone enters the bloodstream it can reach almost any cell in the body. However, each hormone affects only certain kinds of c

Explain about the saponins, Explain about the Saponins? These are a div...

Explain about the Saponins? These are a diverse group of compounds commonly found in legumes like soybean, lentils, chickpeas, peanuts and alfalfa sprouts. They are also presen

What is the ph inside the stomach, What is the pH inside the stomach? Why i...

What is the pH inside the stomach? Why is there a need to keep that pH level? How is it maintained? Which are the cells that produce that pH? The normal pH of the gastric juice

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd