Genetic defect in pyruvate dehydrogenase, Biology

Assignment Help:

Genetic Defect in Pyruvate Dehydrogenase

A defed in any of  the protein subunits of PDH can result in decrease or complete loss of  activity. Severe cases are usually fatal. Symptoms  of deficiency include:

a)  Lactic acidosis, and

b)  Neurologic disorders.  .

Chronic alcoholics suffer  fiom  the deficiency of,thiamin,  which results  in the  accumulation of pyruvic acid. Excess pyruvate is also reduced to lactate leading to potentially fatal pyruvic and lactic acidosis.

 


Related Discussions:- Genetic defect in pyruvate dehydrogenase

Explain procedure for acid fast staining, Explain Procedure for Acid Fast S...

Explain Procedure for Acid Fast Staining? Carry out the exercise using the steps enumerated herewith. 1. Label the clean, non-greasy slides and make smears of M. smegmatis,

Explain the toxicity of vitamin e, Explain the Toxicity of Vitamin E? ...

Explain the Toxicity of Vitamin E? Vitamin E is relatively non-toxic. Adults tolerate doses as high as 100 to 1,000 IU per day. However, adverse effects such as muscle weaknes

Respiration - metabolism of pollen tubes, Respiration - Metabolism of Polle...

Respiration - Metabolism of Pollen Tubes In the unpollinated pistils of Hippeastrum hybridum very high O 2 , tension exists from stigma down through most of the style. During

Defina about the lipid metabolism, Defina about the Lipid Metabolism? A...

Defina about the Lipid Metabolism? Animal studies consistently show a hypotriglyceridenlic effect although equivocal results have been seen with healthy humans. Hypotriglycerid

Determination of proteins and amino acid content in foods, Define Methods o...

Define Methods of Determination of Proteins and Amino Acid Content in Foods? The methods for protein quality evaluation are grouped under the following headings: I) Analytic

Pituitary disorders, PITUITARY DISORDERS - (a) Pituitary Dwarfism . It...

PITUITARY DISORDERS - (a) Pituitary Dwarfism . It is caused by the deficiency of growth hormones (GH) from childhood. It is characterised by small but well porportioned body a

Define the growth charts of infant, Define the Growth Charts of Infant? ...

Define the Growth Charts of Infant? Besides identifying growth faltering, growth charts also provide the following information: 1) The growth is considered normal or satisfa

Explain the hydrophobic grid membrane filter (hgmf), Explain the Hydrophobi...

Explain the Hydrophobic Grid Membrane Filter (HGMF)? It is also used to enumerate microorganisms from a variety of food samples. By using this method, organisms as few as 10 ce

What occurs to transcription at the lac operon, What happens to transcripti...

What happens to transcription at the lac operon when lactose is absent and why? What happens to transcription at the lac operon when lactose is present and why? What happens

What is guided bone regeneration, What is Guided bone regeneration Gui...

What is Guided bone regeneration Guided bone regeneration (GBR) allow the practitioner to place implants in patients who would not have received this treatment option a few y

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd