Genetic defect in pyruvate dehydrogenase, Biology

Assignment Help:

Genetic Defect in Pyruvate Dehydrogenase

A defed in any of  the protein subunits of PDH can result in decrease or complete loss of  activity. Severe cases are usually fatal. Symptoms  of deficiency include:

a)  Lactic acidosis, and

b)  Neurologic disorders.  .

Chronic alcoholics suffer  fiom  the deficiency of,thiamin,  which results  in the  accumulation of pyruvic acid. Excess pyruvate is also reduced to lactate leading to potentially fatal pyruvic and lactic acidosis.

 


Related Discussions:- Genetic defect in pyruvate dehydrogenase

Explain acylglycerols, Explain acylglycerols The most abundant class of...

Explain acylglycerols The most abundant class of food lipids is the acylglycerols, also known as glycerol esters of fatty acids, which dominate the composition of depot fats in

Frog, why frog respire through skin

why frog respire through skin

Horse diseases-japanese encephalitis, Japanese encephalitis The Japane...

Japanese encephalitis The Japanese encephalitis is a mosquito-born flavivirus infection that causes encephalitis in human and equines and abortion in pigs, caused by Japanese

Interdependance, Give an example of how two organisms are interdependent.

Give an example of how two organisms are interdependent.

Explain the food applications of carrageenan, Food Applications of Carragee...

Food Applications of Carrageenan Carrageenan consists of a family of hydrocolloids, which have different properties and it has a wide variety of uses. Some examples of properti

Excretion, what is the excretory organ of lizard

what is the excretory organ of lizard

What is harmonious ecological interaction, Q. What is inharmonious ecologic...

Q. What is inharmonious ecological interaction? The negative or Inharmonious ecological interaction is that in which at least one of the participating beings is harmed. Q.

Why is the cytoplasm of sperm cells very reduced, Q. Why is the cytoplasm o...

Q. Why is the cytoplasm of sperm cells very reduced? Why do mitochondria of sperm cells concentrate in the base of the flagellum? The reduced cytoplasm of sperm cells reduces t

Investigation of aortic regurgitation by exercise testing, Q. Investigation...

Q. Investigation of aortic regurgitation by Exercise Testing? It is helpful in assessing functional capacity, symptom status and hemodynamic effects in patients with severe AR

Preparation of the standard curve for haemoglobin, Preparation of the stand...

Preparation of the standard curve for haemoglobin? Label 6 clean dry rest tubes and label them as S1 -S6 Add 5 ml of Drabkin's solution to test tube numbers S2 - S6

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd