Genetic defect in pyruvate dehydrogenase, Biology

Assignment Help:

Genetic Defect in Pyruvate Dehydrogenase

A defed in any of  the protein subunits of PDH can result in decrease or complete loss of  activity. Severe cases are usually fatal. Symptoms  of deficiency include:

a)  Lactic acidosis, and

b)  Neurologic disorders.  .

Chronic alcoholics suffer  fiom  the deficiency of,thiamin,  which results  in the  accumulation of pyruvic acid. Excess pyruvate is also reduced to lactate leading to potentially fatal pyruvic and lactic acidosis.

 


Related Discussions:- Genetic defect in pyruvate dehydrogenase

Problem of survival among cheetahs, Once quite widespread throughout Asia a...

Once quite widespread throughout Asia and Africa, there has been a large reduction of the cheetah's habitat and numbers though it is still seen in widely separated areas of Africa.

Nutritional deficiency, Iron deficiency should be treated with supplemental...

Iron deficiency should be treated with supplemental iron. • Osteoporosis should be treated with calcium and vitamin D supplements. • Depending on individual factors, patien

Can a chemical reaction the free energy change to mol, In a chemical reacti...

In a chemical reaction the free energy change (/\Go') is -40 jk/mol and the entropy factor T/\S is 15 kj/mol. the enthalpy change /\H for the reaction is a. 25 kj/mol b.-25 k

Fats , FATS ( = True Fats, Triglycerides, Neutral Fats) They are es...

FATS ( = True Fats, Triglycerides, Neutral Fats) They are esters of fatty acids and 3-carbon trihydric alcohol glycerol (= glycerine). T rue fat is also called trig

Which of the vertebrate classes are warm-blooded, Which of the vertebrate c...

Which of the vertebrate classes (a) are 'warm-blooded', (b) reproduce by laying eggs?   (a) Birds and mammals are 'warm-blooded'. (b) Fish, Amphibia, Reptiles

Define observation for benedict test - carbohydrates, Define Observation fo...

Define Observation for Benedict Test - Carbohydrates? An insoluble reddish brown precipitate of cuprous oxide will be obtained. This is similar to Fehling's test. The reddis

Measurement of colour in foods, Q. Measurement of Colour in Foods? A nu...

Q. Measurement of Colour in Foods? A number of instruments are used for colour measurements in food.  a) A simple method is to match the colour of a food with coloured chips

Oxidative phosphorylation, Oxidative phosphorylation Oxidative phosphor...

Oxidative phosphorylation Oxidative phosphorylation is a metabolic pathway which uses energy released through the oxidation of nutrients to generate adenosine triphosphate (ATP

Hepatitis, He p atitis Hepatitis is defined as degenerative/ inflamma...

He p atitis Hepatitis is defined as degenerative/ inflammatory processes of the liver. The clinical manifestations associated with hepatic dysfunctions results from impairmen

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd