Genetic defect in pyruvate dehydrogenase, Biology

Assignment Help:

Genetic Defect in Pyruvate Dehydrogenase

A defed in any of  the protein subunits of PDH can result in decrease or complete loss of  activity. Severe cases are usually fatal. Symptoms  of deficiency include:

a)  Lactic acidosis, and

b)  Neurologic disorders.  .

Chronic alcoholics suffer  fiom  the deficiency of,thiamin,  which results  in the  accumulation of pyruvic acid. Excess pyruvate is also reduced to lactate leading to potentially fatal pyruvic and lactic acidosis.

 


Related Discussions:- Genetic defect in pyruvate dehydrogenase

Physiological changes - consequences of aging, Physiological Changes - Cons...

Physiological Changes - Consequences of Aging Various physiological regulatory mechanisms show decreased efficiency due to aging. For instance, normally the glucose level in t

Importance of nutritional interaction, Importance  of nutritional interact...

Importance  of nutritional interaction :- Now  being  realized.  Some  nutrients  are antagonistic to each other whereas others act synergistically. Examples of uniquely related

Evolution, what is ontogeny recapitulates phyloeny

what is ontogeny recapitulates phyloeny

Explain nutritional support management for gastric cancer, Explain Nutritio...

Explain Nutritional Support Management for gastric cancer? The 'dumping syndrome' can be greatly minimized or prevented by adhering strictly to an antidumping dict. In general,

What is genomics , We are living in an unprecedented age of biological ...

We are living in an unprecedented age of biological discovery and the application of biological knowledge.   Programmed DNA sequencing delivered, in the year of  2001 over the 2.6

Phases of respiration in animals, Phases of Respiration in Animals The...

Phases of Respiration in Animals The procedures of respiration in these animals have the following phases. i) External respiration is usually described as breathing. It inv

Grading of stenosis and grading of coronary artery disease, Q. Grading of S...

Q. Grading of Stenosis and Grading of Coronary Artery Disease? Multiple views are necessary to quantify coronary stenosis accurately. Further, there should be no foreshortening

Micro biology, explane the role of nitrogenase enzyme

explane the role of nitrogenase enzyme

Construct cdna samples, Once you have identified a few relevant mRNA specie...

Once you have identified a few relevant mRNA species, you wish to more closely examine their messages by sequencing. You do not have the time to search the genome and isolate the D

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd