Genetic defect in pyruvate dehydrogenase, Biology

Assignment Help:

Genetic Defect in Pyruvate Dehydrogenase

A defed in any of  the protein subunits of PDH can result in decrease or complete loss of  activity. Severe cases are usually fatal. Symptoms  of deficiency include:

a)  Lactic acidosis, and

b)  Neurologic disorders.  .

Chronic alcoholics suffer  fiom  the deficiency of,thiamin,  which results  in the  accumulation of pyruvic acid. Excess pyruvate is also reduced to lactate leading to potentially fatal pyruvic and lactic acidosis.

 


Related Discussions:- Genetic defect in pyruvate dehydrogenase

Scrapie, Scrapie This is a chronic fatal disease of sheep and occasiona...

Scrapie This is a chronic fatal disease of sheep and occasionally of goats caused by a Prion agent similar to BSE. The disease is reported from Europe, North America and in a f

Gaseous exchange, Gaseous Exchange Gaseous exchange is take place on b...

Gaseous Exchange Gaseous exchange is take place on by both mantle and the gills. The gills of most bivalves are highly changed for filter feeding. They are derived from the pr

Explain diseases of pericardium, Q. Explain Diseases of pericardium? Pe...

Q. Explain Diseases of pericardium? Pericardium is the sac covering the heart. Pericardium consists of two layers-the visceral pericardium (epicardium) and the parietal pericar

Uncomplicated q wave mi-coronary artery bypass surgery, Uncomplicated Q ...

Uncomplicated Q Wave MI :  CABG has very little place in cases of uncomplicated Q wave myocardial infarction. However the place of urgent surgery has to be compared to thrombo

Determine the prosthodontic considerations, Prosthodontic considerations ...

Prosthodontic considerations In order to achieve good results, understated features should always be examinated. 1. Smile Line: A high smile line increases the esthetic

Explain diffusion and osmosis in cell structure, Explain Diffusion and Osmo...

Explain Diffusion and Osmosis in cell structure? Diffusion and Osmosis :  Diffusion through a cell membrane occurs as it does elsewhere, from an area of high concentration of

What is the carbon cycle, Q. What is the carbon cycle? The carbon cycle...

Q. What is the carbon cycle? The carbon cycle represents the recycling and circulation of the chemical element carbon in nature as a result of the action of living beings. T

What is the embryonic development called, What are the cells produced in th...

What are the cells produced in the first stage of the embryonic development called? The cells that result from the cleavage (the first stage of the embryonic development) are k

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd