Genetic defect in pyruvate dehydrogenase, Biology

Assignment Help:

Genetic Defect in Pyruvate Dehydrogenase

A defed in any of  the protein subunits of PDH can result in decrease or complete loss of  activity. Severe cases are usually fatal. Symptoms  of deficiency include:

a)  Lactic acidosis, and

b)  Neurologic disorders.  .

Chronic alcoholics suffer  fiom  the deficiency of,thiamin,  which results  in the  accumulation of pyruvic acid. Excess pyruvate is also reduced to lactate leading to potentially fatal pyruvic and lactic acidosis.

 


Related Discussions:- Genetic defect in pyruvate dehydrogenase

Define observation or inference for fehling's test, Define Observation or I...

Define Observation or Inference for fehling's test? An insoluble reddish brown precipitate of cuprous oxide will be obtained. The reddish brown precipitate indicates the presen

Enzymology, Ethylene glycol is a poison that causes about fifty deaths a ye...

Ethylene glycol is a poison that causes about fifty deaths a year in the United States. Treating people who have drunk ethylene glycol with massive doses of ethanol can save their

Objectives of diabetes counselling, Objectives of Diabetes Counselling    ...

Objectives of Diabetes Counselling      1.  Facilitating decision to start treatment and change life style 2.  Providing psychological, social and emotional support for a.

Describe class agnatha in details, Describe Class Agnatha in details? C...

Describe Class Agnatha in details? Class Agnatha takes its name from the Greek word "gnathos," which means jaw, and "a," which is the prefix for "without." These jawless fishes

Describe arteriovenous continuous murmur, Describe Arteriovenous Continuous...

Describe Arteriovenous Continuous Murmur? Arteriovenous Continuous Murmur :  These can be congenital as in coronary artery fistula entering RA/RV/PA, sinus of valsalva to rig

What is the structural flat representation of an amino acid, What is the st...

What is the structural flat representation of an amino acid molecule? An amino acid has a central carbon to which a carboxyl group binds on a side and to which a -R (variable r

Harmons, which was the first harmone discovered#

which was the first harmone discovered#

Homeostasis, using a specific example describe how hormones have an importa...

using a specific example describe how hormones have an important role in the regulation of body functions and also, what happens if there is an over secretion or an under secretion

Lumpy skin disease, L u mp y skin disease The disease, reported from...

L u mp y skin disease The disease, reported from Sudan in 1970 and Egypt in 1988, is caused by a member of the Capripox virus. It affects cattle and is restricted to African

Digestive gland, which system give the signals to salivary gland

which system give the signals to salivary gland

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd