Genetic defect in pyruvate dehydrogenase, Biology

Assignment Help:

Genetic Defect in Pyruvate Dehydrogenase

A defed in any of  the protein subunits of PDH can result in decrease or complete loss of  activity. Severe cases are usually fatal. Symptoms  of deficiency include:

a)  Lactic acidosis, and

b)  Neurologic disorders.  .

Chronic alcoholics suffer  fiom  the deficiency of,thiamin,  which results  in the  accumulation of pyruvic acid. Excess pyruvate is also reduced to lactate leading to potentially fatal pyruvic and lactic acidosis.

 


Related Discussions:- Genetic defect in pyruvate dehydrogenase

Disorders of gonads, DISORDER S OF THE GONADS Hypogonadism. Inadequa...

DISORDER S OF THE GONADS Hypogonadism. Inadequate gonadal function is called hypogonadism. It is due to defects in, or injury to the hypothalamus, the pituitary gland, of th

Human skeleton, what are the main coponents of human skeleton?

what are the main coponents of human skeleton?

A dihybrid cross yields 320 f2 offspring, A dihybrid cross yields 320 F2 of...

A dihybrid cross yields 320 F2 offspring. How many are expected to resemble the homozygous recessive parental?

How dietary iron is absorbed in my blood vessels, What pathway does dietary...

What pathway does dietary iron follow in blood vessels

Define application of nutrition knowledge in geld of sports, Define Applica...

Define Application of Nutrition Knowledge in Geld of Sports? By the time you are ready to do this unit, you have been exposed to a good deal of the basic knowledge of nutrition

Illustrate temporal digital subtraction radiography, Q. Illustrate Temporal...

Q. Illustrate Temporal digital subtraction radiography? Temporal digital subtraction radiography (SR) is a radiographic technique that enable two radiographs made at different

What are the phospholipids, Q. What are the phospholipids? Phospholipid...

Q. What are the phospholipids? Phospholipids are molecules made of glycerol bound to one phosphate group and to two long molecules of fatty acids. hence, phospholipids are amph

Define regulation of malice enzyme by starvation & refeeding, Define regula...

Define regulation of malice enzyme by starvation & refeeding? ME catalyzes the oxidative decarboxylation of malate to pyruvate and CO 2 simultaneously generating the reduced

What is phellogen, What is phellogen? What is its function? Phellogen, ...

What is phellogen? What is its function? Phellogen, also called as cork cambium, is the meristematic plant tissue responsible for the formation of the periderm (the covering of

Bio geographical evidences, The main points which is based on the seminar...

The main points which is based on the seminar topic Bio geographical evidences

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd