Genetic defect in pyruvate dehydrogenase, Biology

Assignment Help:

Genetic Defect in Pyruvate Dehydrogenase

A defed in any of  the protein subunits of PDH can result in decrease or complete loss of  activity. Severe cases are usually fatal. Symptoms  of deficiency include:

a)  Lactic acidosis, and

b)  Neurologic disorders.  .

Chronic alcoholics suffer  fiom  the deficiency of,thiamin,  which results  in the  accumulation of pyruvic acid. Excess pyruvate is also reduced to lactate leading to potentially fatal pyruvic and lactic acidosis.

 


Related Discussions:- Genetic defect in pyruvate dehydrogenase

ANIMAL RESPIRATION, WHAT IS THERE BETWEEN THE TRACHEA OF COCKROACH AND RABB...

WHAT IS THERE BETWEEN THE TRACHEA OF COCKROACH AND RABBIT

What is implant prior to stage 2 surgery, Enumerate the different means of ...

Enumerate the different means of evaluating the implant prior to stage 2 surgery. The Different means for evaluating the implant prior to stage 2; i) Radiographic evaluation

Why is it true that of the 28 chromosomes in an ovum, A species has a diplo...

A species has a diploid chromosome number of 56, WHY is it true that of the 28 chromosomes in an ovum, 14 are always paternal?

How infections and infestations cause pem, How Infections and Infestations ...

How Infections and Infestations cause PEM? Childhood infections (viral/bacterial) and parasitic infestations are almost always associated with PEM. These cause anorexia (loss o

Intracellular sodium concentration of the motor neuron, Intracellular sodiu...

Intracellular sodium concentration of the motor neuron A complete motor neuron is removed from a frog and placed in normal physiological saline at 1 AM.  The neuron is healthy.

Digestive system, I want to know how does our digestive system work

I want to know how does our digestive system work

What are cytokines, What are Cytokines? Cytokines are polypeptides, whi...

What are Cytokines? Cytokines are polypeptides, which influence the proliferation, differentiation, metabolism and activation of cells. There are three areas in cancer that hav

Define reagents for preparation of phosphate buffers, Define Reagents for P...

Define Reagents for Preparation of Phosphate Buffers? Buffer solutions of pH4, pH7 and pH 9.18 phosphate buffer solution: 0.1 M disodium hydrogen phosphate or Na 2 HPO 4

Define serum vitamin a content, Define Serum Vitamin A Content? Assessm...

Define Serum Vitamin A Content? Assessment of serum vitamin A content is the most reliable criterion Tor assessing vitamin A status. Serum levels indicative of various degrees

Cultural and religious values, Wildlife has influenced language, art, relig...

Wildlife has influenced language, art, religion and social customs of many societies worldwide, and wild animals figure prominently in many cultures even today. In all cultures of

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd