Genetic defect in pyruvate dehydrogenase, Biology

Assignment Help:

Genetic Defect in Pyruvate Dehydrogenase

A defed in any of  the protein subunits of PDH can result in decrease or complete loss of  activity. Severe cases are usually fatal. Symptoms  of deficiency include:

a)  Lactic acidosis, and

b)  Neurologic disorders.  .

Chronic alcoholics suffer  fiom  the deficiency of,thiamin,  which results  in the  accumulation of pyruvic acid. Excess pyruvate is also reduced to lactate leading to potentially fatal pyruvic and lactic acidosis.

 


Related Discussions:- Genetic defect in pyruvate dehydrogenase

Mucoproteins (glycoproteins), MUCOPROTEIN S (GLYCOPROTEINS) Protein...

MUCOPROTEIN S (GLYCOPROTEINS) Proteins having conjugated mucosaccharides that form viscous mucus or mucoid secretions. The gastric mucus or mucoprotein is resistant to p

Cutaneous larva migrans, Cutaneous larva migrans Cutaneous larva migrans, ...

Cutaneous larva migrans Cutaneous larva migrans, also known as creeping eruption, creeping verminous dermatitis or serpiginous eruption, is caused by larvae of many nematodes, viz

Explain first stage of the embryonic development, Q. What is the cell divis...

Q. What is the cell division during the first stage of the embryonic development called? How is this stage characterized? The cell division in the first stage of the embryonic

Explain phylum cyanobacteria, Phylum Cyanobacteria Cyanobacteria  are p...

Phylum Cyanobacteria Cyanobacteria  are prokaryotes,  but  they are not  like bacteria  in  the usual  sense of  the word.  The cyanobacteria  lack chloroplasts,  and  their  l

Explain the assessment of zn status, Explain the Assessment of Zn Status? ...

Explain the Assessment of Zn Status? Sensitive indices for assessing zinc status are unknown at present. Static indices, such as zinc concentration in plasma, blood cells and h

How are poriferans characterized, Q. Concerning digestion how are poriferan...

Q. Concerning digestion how are poriferans characterized? Sponges are diverse from other animals since they present only intracellular digestion. Do they release digestive enzy

Heart of cockroach, Heart of cockroach: In cockroach, heart is situa...

Heart of cockroach: In cockroach, heart is situated in pericardial sinus. It has13 chambers These are one behind the other. Each chamber opens into preceeding one. The

Show appearance of food product, Q. Show Appearance of food product? Ap...

Q. Show Appearance of food product? Appearance can be judged by the eye. Appearance factors include such things as size, colour, uniformity, absence of any defect, shape, whole

Theileriosis, T h e i l e r io s i s It is also referred as t...

T h e i l e r io s i s It is also referred as tropical theileriosis and results in fever, enlargement of superficial lymphnodes, anaemia and jaundice. E tiolo

Why is the cleavage in mammals as simple homoplastic, Why do the sons of a ...

Why do the sons of a haemophiliac father never vary from this trait? Why is the cleavage in mammals referred as simple homoplastic?

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd