Genetic defect in pyruvate dehydrogenase, Biology

Assignment Help:

Genetic Defect in Pyruvate Dehydrogenase

A defed in any of  the protein subunits of PDH can result in decrease or complete loss of  activity. Severe cases are usually fatal. Symptoms  of deficiency include:

a)  Lactic acidosis, and

b)  Neurologic disorders.  .

Chronic alcoholics suffer  fiom  the deficiency of,thiamin,  which results  in the  accumulation of pyruvic acid. Excess pyruvate is also reduced to lactate leading to potentially fatal pyruvic and lactic acidosis.

 


Related Discussions:- Genetic defect in pyruvate dehydrogenase

Agro industrial-post-partum anoestrus, Post-partum anoestrus Reproduct...

Post-partum anoestrus Reproductive efficiency among animals greatly depends upon detection of estrus. This is even more important in reference to small herds managed under tro

Electro magnetic radiation, Electro magnetic radiation Light is one ...

Electro magnetic radiation Light is one form of energy. The light rays consist of tiny particles called photons. The energy carried by photon is called quantum. Light

Energy storage, Energy Storage As we said above, food intake and ener...

Energy Storage As we said above, food intake and energy expenditure for animals is approximately equal. If energy expenditure exceeds food intake, then the excess energy is t

What are pioneer species, Q. What are pioneer species? What is the role of ...

Q. What are pioneer species? What is the role of the pioneer species? The Pioneer species are those first species that colonize places where previously there were no living bei

Why does the ingestion of vegetable fibers improve the bowel, Why does the ...

Why does the ingestion of vegetable fibers improve the bowel habit in people that suffer from hard stools? Some types of plant fibers are not absorbed by the intestine but play

Define the intradermal dye test, Define the Intradermal Dye Test? The r...

Define the Intradermal Dye Test? The rate of decolouration of a small quantity of the dye, 2, 6- dichlorophenol injected intradermaly is an index of the ascorbic acid nutrition

Homeostasis, using a specific example describe how hormones have an importa...

using a specific example describe how hormones have an important role in the regulation of body functions and also, what happens if there is an over secretion or an under secretion

Deficiency diseases-iron deficiency, Iron deficiency Iron plays an ess...

Iron deficiency Iron plays an essential role in oxygen transport in the body as a constituent of haemoglobin where nearly 60% of the body iron is found. Apart from oxygen tran

Difference between diastolesystole and systole, Q. What is the difference b...

Q. What is the difference between diastoleSystole and systole and diastole are the two stages into which the cardiac cycle is divided Diastole is the stage of the cardiac cycle

Do echinoderms present external or internal fecundation, Q. Do echinoderms ...

Q. Do echinoderms present external or internal fecundation? Is there sex division among individuals? The fecundation in echinoderms is external, gametes are liberated in water

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd