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Once the total volume of an individual vessel has been established the detailed dimensions or mechanical design can be performed. Much of this is based on "Rules of Thumb" built from years of experience. A summary is provided below for a standard Stirred Tank Reactor (STR).
Perhaps the most important factor in the mechanical design of a bioreactor is the height to diameter or aspect ratio as this determines many of the other important bioreactor characteristics. There are relative advantages of increasing either the height or diameter.
(a) Increasing height
i. increases the hydrostatic pressure
Advantage - increases solubility of oxygen
Disadvantage - increases solubility of other gases which may be toxic, e.g. CO2 ii. allows more agitators
Advantage - better power development
Disadvantage - can lead to poor mixing due to compartmentalisation (b) Increasing diameter
i. lowers the superficial (linear) gas velocity
Disadvantage - poor mixing, oxygen transfer ii. reduces wall surface area (per unit volume) available for heat transfer
Disadvantage - leads to temperature control problems
Requirements for Standard Interface The interface must be capable of handling all kinds of manufacturing data. There should be no information loss when data is transf
The following data was obtained from an orthogonal cutting test : Rake angle = 20o, Depth of cut = 6 mm Feed rate = 025 mm/rev Chip length before cutting = 29.4 mm Chip
To design a cantilevered truss to support the loads shown in the figures, two layouts are proposed as shown in Figs. A and B. All truss members are steel with allowable stress of 2
limitations of first law of thermodynamics: There are some limitations of First Law of Thermodynamics. 1. When a closed system undergoes thermodynamic cycle, the average he
A tensile test on a specimen having an initial diameter of 13.11 mm and an initial gauge length of 200.0 mm, gave the following data:
1) State five factors that must be considered when choosing a material. Discuss the importance to the engineer of each of these factors. 2) An engineer is planning to design a s
Give justification toward the development of rapid prototyping?
bendind moment equation
wath is diesel cycle with diagram
a steel bar is
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