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Once the total volume of an individual vessel has been established the detailed dimensions or mechanical design can be performed. Much of this is based on "Rules of Thumb" built from years of experience. A summary is provided below for a standard Stirred Tank Reactor (STR).
Perhaps the most important factor in the mechanical design of a bioreactor is the height to diameter or aspect ratio as this determines many of the other important bioreactor characteristics. There are relative advantages of increasing either the height or diameter.
(a) Increasing height
i. increases the hydrostatic pressure
Advantage - increases solubility of oxygen
Disadvantage - increases solubility of other gases which may be toxic, e.g. CO2 ii. allows more agitators
Advantage - better power development
Disadvantage - can lead to poor mixing due to compartmentalisation (b) Increasing diameter
i. lowers the superficial (linear) gas velocity
Disadvantage - poor mixing, oxygen transfer ii. reduces wall surface area (per unit volume) available for heat transfer
Disadvantage - leads to temperature control problems
Calculate tensions in chain and chord - Mechanics: A lamp of mass 1Kg is hung from the ceiling by a chain and is pulled aside by horizontal chord until the chain makes an ang
how to design spindle
5. Calculate and draw the Shear force and Bending moment diagrams for the loaded beam and determine the maximum moment M and its location x from left end
Q. Categorization of Geometric models? Modern CAD systems define objects in 3-D. Thus, the designer can construct 3-D model of objects conveniently and store the database of th
with usual notations the effort lost due to friction is given by A) P-W/V.R B) P×V.R-W C) P-W×V.R D) P+W/V.R
Process Selection and Sequencing In this, some factors, which have an influence in all processes, are discussed. The factors include size, shape complexity, tolerances and produ
Describe the basic concept of descriptive interface Descriptive interfaces are the window to other CAD systems, to the master databases or to the manufacturing activities. The
What is NWCM
how I can formulate mathematically the risk management in demand uncertainty of short life cycle product.
Nominal Strain and True Strain: Nominal Strain is ratio of change in length per initial length. Nominal strain = Change in length / Initial length = Δ L / L
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