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Once the total volume of an individual vessel has been established the detailed dimensions or mechanical design can be performed. Much of this is based on "Rules of Thumb" built from years of experience. A summary is provided below for a standard Stirred Tank Reactor (STR).
Perhaps the most important factor in the mechanical design of a bioreactor is the height to diameter or aspect ratio as this determines many of the other important bioreactor characteristics. There are relative advantages of increasing either the height or diameter.
(a) Increasing height
i. increases the hydrostatic pressure
Advantage - increases solubility of oxygen
Disadvantage - increases solubility of other gases which may be toxic, e.g. CO2 ii. allows more agitators
Advantage - better power development
Disadvantage - can lead to poor mixing due to compartmentalisation (b) Increasing diameter
i. lowers the superficial (linear) gas velocity
Disadvantage - poor mixing, oxygen transfer ii. reduces wall surface area (per unit volume) available for heat transfer
Disadvantage - leads to temperature control problems
why there is heat is not completely converted into work in ideal case?
cause effect remedies
a) What are essential needs of a job evaluation plan. Illustrate the point plan method b) Describe factor comparison method of job evaluation. a) What are basic objectives an
Illustrate the following terms:- a) Mechanism and Inversion b) Slip and Creep of belt drive c) Centrifugal Tension of belt drive d) Initial Tension of belt drive
operation
Q. The area of the hysteresis loop of a given magnetic material is 50cm 2 with the two axes scaled as 1cm = 20AT and 1cm = 50mWb, for 50Hz frequency find the total hysteresis
Modal Dispersion in Step-Index Fibers Determine the core radius of a multi-mode step index fiber with a numerical aperture NA = 0.1 if the number of modes M = 5000 when the wave
Principles Governing Rural Roads Design Standards: The following principles should govern in design of rural roads : (a) Rural Roads are low volume facility serving an acc
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Computer-Aided Design (CAD) CAD is used in design and development of new products in a diversity of applications both at commercial/industrial and on a home basis. Illustration
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