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Once the total volume of an individual vessel has been established the detailed dimensions or mechanical design can be performed. Much of this is based on "Rules of Thumb" built from years of experience. A summary is provided below for a standard Stirred Tank Reactor (STR).
Perhaps the most important factor in the mechanical design of a bioreactor is the height to diameter or aspect ratio as this determines many of the other important bioreactor characteristics. There are relative advantages of increasing either the height or diameter.
(a) Increasing height
i. increases the hydrostatic pressure
Advantage - increases solubility of oxygen
Disadvantage - increases solubility of other gases which may be toxic, e.g. CO2 ii. allows more agitators
Advantage - better power development
Disadvantage - can lead to poor mixing due to compartmentalisation (b) Increasing diameter
i. lowers the superficial (linear) gas velocity
Disadvantage - poor mixing, oxygen transfer ii. reduces wall surface area (per unit volume) available for heat transfer
Disadvantage - leads to temperature control problems
Q. What do you mean by Velocity - Area Method? Out of the above four categories, velocity area method is most widely used and provides more accurate results. Requirements of a
Processing Sequence for Manufacturing Coupling Nut Referring to the Figure 12 below, we now illustrate the processing sequence for manufacturing coupling nut.
The Baseline Dimension Command You can use this command to generate a series of dimensions from a single base point. You must already have created the first dimension in the se
Simple Rules FIFO (first in first out) PN j = t aj SPT (shortest processing time) PN j = o j ODD (earliest operation due dates) PN j = t dj EDD (earliest job due
Q. Show Geographic constraints of the plant? The layout of process units will be influenced by the geographic constraints of the site. Spacing is required between plant facilit
limitations of euler''s theory
How is a micrometer used?
Determine ratio between mass flow rate to condensing steam: In steam power plant, the steam 0.1 bar and 0.95 dry enters condenser and leaves as saturated liquid at 0.1 bar an
Define the Adjustable auger mechanisms They improved mounting arrangement for the auger and auger drive mechanism of a floating screed type asphalt paver. And they provide actu
With the aid of a sketch, describe the motion of a solid particle settling in a liquid and discuss the effect on it of applying a centrifugal force. Define the terms Separating
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