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Once the total volume of an individual vessel has been established the detailed dimensions or mechanical design can be performed. Much of this is based on "Rules of Thumb" built from years of experience. A summary is provided below for a standard Stirred Tank Reactor (STR).
Perhaps the most important factor in the mechanical design of a bioreactor is the height to diameter or aspect ratio as this determines many of the other important bioreactor characteristics. There are relative advantages of increasing either the height or diameter.
(a) Increasing height
i. increases the hydrostatic pressure
Advantage - increases solubility of oxygen
Disadvantage - increases solubility of other gases which may be toxic, e.g. CO2 ii. allows more agitators
Advantage - better power development
Disadvantage - can lead to poor mixing due to compartmentalisation (b) Increasing diameter
i. lowers the superficial (linear) gas velocity
Disadvantage - poor mixing, oxygen transfer ii. reduces wall surface area (per unit volume) available for heat transfer
Disadvantage - leads to temperature control problems
Discover modulus of elasticity of the composite: A composite of glass fibres and epoxy contain all fibres laid along the length and is needed to carry a stress of 1200 MPa. Th
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work of combination die
(i) Hydraulic press: This can be used to lift a heavy load placed on the platform of larger piston or to press the things placed among the piston and the heavy platfor
Total tension in cable of the elevator: An elevator having weight 5000N is ascending with an acceleration of 3m/sec 2 . During this ascent its operator which is having weig
Q. External coatings on vessels? All pressure vessels that will be installed underground shall have an external coating applied according to the following procedure: • All e
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The average heat transfer co efficient for flow of 100 o C air over a flat plate is calculated by observing the temperature time history of a 3mm thick copper slab exposed 100 o
Determine the Properties of foundation Soil profile together with natural type and properties of each strata will have a bearing on the choice of foundation. The fact that loa
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