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Once the total volume of an individual vessel has been established the detailed dimensions or mechanical design can be performed. Much of this is based on "Rules of Thumb" built from years of experience. A summary is provided below for a standard Stirred Tank Reactor (STR).
Perhaps the most important factor in the mechanical design of a bioreactor is the height to diameter or aspect ratio as this determines many of the other important bioreactor characteristics. There are relative advantages of increasing either the height or diameter.
(a) Increasing height
i. increases the hydrostatic pressure
Advantage - increases solubility of oxygen
Disadvantage - increases solubility of other gases which may be toxic, e.g. CO2 ii. allows more agitators
Advantage - better power development
Disadvantage - can lead to poor mixing due to compartmentalisation (b) Increasing diameter
i. lowers the superficial (linear) gas velocity
Disadvantage - poor mixing, oxygen transfer ii. reduces wall surface area (per unit volume) available for heat transfer
Disadvantage - leads to temperature control problems
A 1.2 m diameter steel pipe carries oil of relative density 0.822 under a head of 70 m of oil. What minimum thickness of 120 MPa (yield stress) steel would be required for a safety
What are the approaches to the design of retaining walls? The approach to the design of retaining walls can be started as follows: a. Chosse a trial dimension of the wall
Defects Involving Inadequate Bonding Lack of fusion Involves lack of complete melting and fusion of some portion of the weld metal in a joint. It may occur either bet
Q. What is Passive Fire Protection? Passive fire protection is defined as any fire protection system that, by its nature, plays an inactive role in protecting personnel and pro
Question: As shown in the figure, the jet transport B is flying north with a velocity v B = 600 km/h when a smaller aircraft A passes underneath the transport headed in the 60
Production of hydrochloric acid
Draw BCC structure and determine its number of atoms per unit cell, co-ordination number and highest edgeradius relation. Draw FCC structure and determine its number of atoms pe
what are the parts of wilson hartnell governor with their designation?
materials for machine tool
Cylinder Bore: The nominal inner diameter of the working cylinder is called the cylinder bore and is designated by the letter D and is usually expressed in millimetre (mm).
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