Fermenter dimensions and mechanical design, Mechanical Engineering

Assignment Help:

Once the total volume of an individual vessel has been established the detailed dimensions or mechanical design can be performed. Much of this is based on "Rules of Thumb"  built from years of experience. A summary is provided below  for a standard Stirred Tank Reactor (STR). 

Perhaps the most important factor in the mechanical design of a bioreactor is the height to diameter  or aspect  ratio  as this determines many of the other important bioreactor characteristics. There are relative advantages of increasing either the height or diameter.

(a) Increasing height

i.  increases the hydrostatic pressure

Advantage - increases solubility of oxygen

Disadvantage - increases solubility of other gases which may be toxic, e.g. CO2
 
ii.  allows more agitators

Advantage - better power development

Disadvantage - can lead to poor mixing due to compartmentalisation
 
(b) Increasing diameter

i. lowers the superficial (linear) gas velocity

Disadvantage - poor mixing, oxygen transfer
 
ii. reduces wall surface area (per unit volume) available for heat transfer

Disadvantage - leads to temperature control problems


Related Discussions:- Fermenter dimensions and mechanical design

Rubber hoses services tips, Rubber Hoses: Fuel or vacuum hoses should be i...

Rubber Hoses: Fuel or vacuum hoses should be installed so that end is bottomed into its fitting which would ensure adequate area for the hose clip to grip the hose beneath the fla

Calculate heat transfer through cylinder wall, Calculate Heat transfer thro...

Calculate Heat transfer through cylinder wall: Calculate change in entropy and heat transfer through cylinder walls, if 0.4m 3 o f a gas at the pressure of 10bar and 20

Describe polythionic acid corrosion, Q. Describe Polythionic Acid Corrosion...

Q. Describe Polythionic Acid Corrosion? Although it is not typically thought of as high temperature corrosion, polythionic acid stress corrosion cracking occurs in areas where

Vessels resting on concrete foundations, Q. Vessels resting on concrete fou...

Q. Vessels resting on concrete foundations? For vessels resting on concrete foundations, the allowable concrete bearing stress shall be 750 psi (5 MPa). The design loadings fo

Explain the use of bare electrode, Q. Explain the use of bare electrode? ...

Q. Explain the use of bare electrode? This type of electrode is also known as plain electrode. No flux covers on this electrode. These types of electrodes are used for D.C. sup

Describe natural and synthetic sand, Q. Describe Natural and Synthetic Sand...

Q. Describe Natural and Synthetic Sand? Natural sand: A natural sand is the on which is available from natural deposits. Only assistive and water need to be added to it to ma

Magnitude of the resultant couple, Magnitude of the resultant couple: ...

Magnitude of the resultant couple: For non-parallel forces also the location of the line of action of resultant may be determined by utilizing R × d = ∑ M o . The magnitu

Piping, difference between pipe and tube

difference between pipe and tube

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd