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Once the total volume of an individual vessel has been established the detailed dimensions or mechanical design can be performed. Much of this is based on "Rules of Thumb" built from years of experience. A summary is provided below for a standard Stirred Tank Reactor (STR).
Perhaps the most important factor in the mechanical design of a bioreactor is the height to diameter or aspect ratio as this determines many of the other important bioreactor characteristics. There are relative advantages of increasing either the height or diameter.
(a) Increasing height
i. increases the hydrostatic pressure
Advantage - increases solubility of oxygen
Disadvantage - increases solubility of other gases which may be toxic, e.g. CO2 ii. allows more agitators
Advantage - better power development
Disadvantage - can lead to poor mixing due to compartmentalisation (b) Increasing diameter
i. lowers the superficial (linear) gas velocity
Disadvantage - poor mixing, oxygen transfer ii. reduces wall surface area (per unit volume) available for heat transfer
Disadvantage - leads to temperature control problems
a) By Gauss elimination method, solve x+2y+z =3 ; 2x+3y+3z =10 ; 3x-y+2z =13 b) Write a ‘C' program to find the solution of the above system of equations by Gauss Jordan meth
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During paddling of a bicycle,the force of friction exerted by the ground on the two wheels is? Ans) Since the rear wheel rotates by itself (we only paddle to rotate the fron wheel
In an orthogonal cutting process, following data were taken. Chip length of 80mm was obtained with an uncut chip length of 200mm and the rake angle used was20 degrees and depth of
HOW HEAT TRANSFER TAKES PLACE
a circle of 40mm roll on horizontal line.draw the curve traced out by the point for 1 complete revolution.the point is vertically above centre of circle
How kleins construction method is different from other type of graphical method
sensitivity of governors
Spark Plug: A spark jumps between the electrodes of the spark plug when the voltage developed by the ignition system reaches the required value. This electrical spark occurs at a
Main characteristics of couple: Sol.: The main characteristics of couple 1. The algebraic sum of the forces, having the couple, is zero. 2. The algebraic sum of moment
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