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Once the total volume of an individual vessel has been established the detailed dimensions or mechanical design can be performed. Much of this is based on "Rules of Thumb" built from years of experience. A summary is provided below for a standard Stirred Tank Reactor (STR).
Perhaps the most important factor in the mechanical design of a bioreactor is the height to diameter or aspect ratio as this determines many of the other important bioreactor characteristics. There are relative advantages of increasing either the height or diameter.
(a) Increasing height
i. increases the hydrostatic pressure
Advantage - increases solubility of oxygen
Disadvantage - increases solubility of other gases which may be toxic, e.g. CO2 ii. allows more agitators
Advantage - better power development
Disadvantage - can lead to poor mixing due to compartmentalisation (b) Increasing diameter
i. lowers the superficial (linear) gas velocity
Disadvantage - poor mixing, oxygen transfer ii. reduces wall surface area (per unit volume) available for heat transfer
Disadvantage - leads to temperature control problems
(a) A 50 mm dia. jet having a velocity of 18 m/sec. impinges without shock on a flat plate inclined at an angle to the axis of jet. If the plate is moving at 5 m/sec in the directi
Metallurgical Compatibility The two facets of property as above could be made analogous crudely to an athlete's wholesome strength, which includes both his physical fitness an
Consideration: 1. From above equation, it is clear that centrifugal tension is not dependent of T1 and T2. It depends upon velocity of the belt. For lower belt speed (that is,
definition and derevation
what is tangential force in metal cutting
Short answer Type. a) Write the difference Between Dry clutch and Wet ? b) What is difference Between Chasis and Frame? c) Illustrate the Future trends in Automobile
Ballast: Ballast is the layer of broken stone provided on the formation on which the sleepers rest. The stones are cubical in shape and pass through 50 mm square mesh. The fu
Design a soda vending machine that can deliver three kinds of soda, A, B and C. All the three soda cost the same amount - 70 cents. The vending machine has four coin slots, one eac
Determine Strain energy stored in coiled helical spring: For a close coiled helical spring subjected to an axial load of 200 N with 10 coils of wire of diameter 18 mm and buil
determine the vertical deflection at end A neglecting shear
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