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Once the total volume of an individual vessel has been established the detailed dimensions or mechanical design can be performed. Much of this is based on "Rules of Thumb" built from years of experience. A summary is provided below for a standard Stirred Tank Reactor (STR).
Perhaps the most important factor in the mechanical design of a bioreactor is the height to diameter or aspect ratio as this determines many of the other important bioreactor characteristics. There are relative advantages of increasing either the height or diameter.
(a) Increasing height
i. increases the hydrostatic pressure
Advantage - increases solubility of oxygen
Disadvantage - increases solubility of other gases which may be toxic, e.g. CO2 ii. allows more agitators
Advantage - better power development
Disadvantage - can lead to poor mixing due to compartmentalisation (b) Increasing diameter
i. lowers the superficial (linear) gas velocity
Disadvantage - poor mixing, oxygen transfer ii. reduces wall surface area (per unit volume) available for heat transfer
Disadvantage - leads to temperature control problems
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Q. Nitrogen storage and vaporizer? Bulk cryogenic storage of nitrogen must be located away from process equipment, preferably at the edge or corner of the process area where fi
A simply supported beam ABC with supports at A and B , 6m apart and with an overhang BC 2 metres long takes uniformly distributed load of 1.5 KN/metre length over the entair length
question no 2,page no 84 of strenght of materials by G H Ryder
Two concentric perforared plates are seperated by a 200mm launder and form the flow exit for a clarifier (figure 1). The inlet water flow of 1200 mcubed/hour into the clarifier is
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what are the limitations of first law of thermodynamics?
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