Extracellular aging, Biology

Assignment Help:

Extracellular Aging

The basic components of extracellular space are mucopolysaccharides and fibrous proteins, particularly collagen and elastin. These proteins are synthesised in connective tissue and secreted out of the tissue. Collagen is predictable to form up to 40% of the body protein and fills the extracellular spaces. It has been recommended as the primary site of age related changes. Remember that collagen molecules are polymers of tropocollagen monomers. Newly polymerised molecules of collagen comprise non-covalent bonds and with age covalent cross-linking takes place between the monomers. Like the age of the organism increases cross-linking becomes much more hard to dissociate and by the time of maturity in mammals collagen becomes insoluble. From maturity to old age; cross-linking is strengthened and its effect can be computed. The age related changes in collagen are indisputable. Age related changes in the structure of collagen influence the functioning and structure of bones, tendon, blood vessels, joints, ligament etc. The inflexibility of collagen fibrils may be a contributory factor for the onset of atherosclerosis and hypertension.


Related Discussions:- Extracellular aging

Build vocabulary, what is the opposite of yield? A.grow B.attack C.ask D.an...

what is the opposite of yield? A.grow B.attack C.ask D.answer

Lipids, Lipids All animal tissues contain lipids or fats as essential...

Lipids All animal tissues contain lipids or fats as essential components of cell membrane. It is also stored in certain tissues. Lipids are body's chief source of energy and

Explain pericardial effusion, Q.Explain Pericardial Effusion? The confi...

Q.Explain Pericardial Effusion? The configuration of the heart in pericardial effusion depends on the volume of fluid and its distribution. It may have a globular or non-speci

What is the function of the collagen fibers, What is the function of the co...

What is the function of the collagen fibers of the connective tissue? There are dissimilar collagen types. The major function of these proteins is to keep the shape and the str

Functions of endoplasmic reticulum, FUNCTIONS OF E.R. (1 )      Mecha...

FUNCTIONS OF E.R. (1 )      Mechanical support - E.R. participates in formation of cytoskeleton with microfilaments, microtubules and intermediate filaments. (2 )

Describe lifetime risk estimation, Describe Lifetime Risk Estimation ? ...

Describe Lifetime Risk Estimation ? Traditional statistical and epidemiological methods of estimating long-term risks do not accurately reflect population burden of disease. Th

Right coronary artery, Right coronary artery arises from the anterior aorti...

Right coronary artery arises from the anterior aortic sinus. It runs down along the anterior part of the coronary sulcus, reaches the lower border of heart turns round the lower bo

Nature of viral diseases, N a ture of viral diseases Viral diseases ...

N a ture of viral diseases Viral diseases are manifested in acute, sub-acute or chronic forms, as frank clinical cases or as latent infections, some of which are fatal. Thes

Predisposing factors and pathphysiology of meningitis, Predisposing Factors...

Predisposing Factors The patients with diabets mellitus, malignancies and those on immunosuppressive drugs have reduced resistance and are more susceptible to develop meningi

Explain the chloride permeability, An impermeable membrane separates one li...

An impermeable membrane separates one liter of a 1M KCl solution in the left compartment from one liter of 1M NaCl solution in the right compartment.  At 2 AM today the membrane be

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd