Explain the Urea Cycle ?

From our discussion above, it is clear that the amino group of all amino acids is ultimately converted to ammonia (NH3). Ammonia is highly toxic to the nervous system. Hence, it must be removed. How is this done? Basically, ammonia combines with C02 to form urea, which is not toxic to the body. Hence, one of the major end products of protein metabolism is urea.

Urea is the major disposal form of amino groups derived from amino acids and accounts for 90% of the nitrogen containing compounds of urine. One of the nitrogen of the urea molecule is supplied by free NH, and the other one by aspartate. Glutamate is the immediate precursor of both ammonia and aspartate nitrogen. The carbon and oxygen of urea are derived from C02. Urea is produced by the liver and is then transported in the blood to the kidneys for excretion in the urine. The steps involved in converting ammonia to urea include

Most of our nitrogenous waste comes from the breakdown of amino acids. This occurs by deamination. Deamination of amino acids results in the production of ammonia (NH3) as we learnt above. Ammonia is an extremely toxic base and its accumulation in the body would quickly be fatal. However, liver contains a system of carrier molecules and enzymes which quickly converts the ammonia (and carbon dioxide) into urea. This is called the 'urea cycle'. This entire sequence of urea cycle is discussed below, along with the enzymes involved in the synthesis of urea.